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8-oxoguanine DNA glycosylase
Summary
- Gene Symbol
-
- OGG1
- Aliases
-
- 8-hydroxyguanine DNA glycosylase
- HMMH
- HOGG1
- MUTM
- OGG1 type 1d
- OGG1 type 1e
- OGG1 type 1g
- OGG1 type 1h
- OGH1
- Organism
- Homo sapiens (human)
Annotation
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to ethanol | ||
| depurination | ||
| cellular response to DNA damage stimulus | ||
| cellular response to cadmium ion | ||
| response to folic acid |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
catabolic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular catabolic process [inference]
heterocycle metabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
phosphorus metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
cellular catabolic process [inference]
heterocycle metabolic process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| nuclear speck | ||
| protein-containing complex | ||
| mitochondrial matrix | ||
| nucleoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| damaged DNA binding | ||
| DNA binding | ||
| 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity | ||
| oxidized purine nucleobase lesion DNA N-glycosylase activity | ||
| RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- glycosylase
- Functional Category
-
- E: Amino acid transport and metabolism
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity |
| DNA repair |
| base-excision repair, AP site formation |
| base-excision repair |
| catalytic activity |
| damaged DNA binding |
| InterPro |
|---|
| 8-oxoguanine DNA glycosylase, N-terminal |
| DNA glycosylase |
| Helix-hairpin-helix, base-excision DNA repair, C-terminal |
| HhH-GPD domain |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0002116 | pterygium | |
| DOID:10283 | prostate cancer | |
| DOID:10591 | pre-eclampsia | |
| DOID:1070 | primary open angle glaucoma | |
| DOID:10763 | hypertension | |
| DOID:11714 | gestational diabetes | |
| DOID:12361 | Graves' disease | |
| DOID:14330 | Parkinson's disease | |
| DOID:1612 | breast cancer | |
| DOID:1793 | pancreatic cancer |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0003745 | Sporadic |
| HP:0005584 | Renal cell carcinoma |
| Disease ID | Disease Name |
|---|---|
| OMIM:144700 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 18294 | MGI:1097693 | MOUSE50088 | ||
| 31806 | FB:FBgn0027864 | |||
| 81528 | RGD:621168 | RATNO30053 | ||
| 460152 | 9598_0:001356 | PANTR30361 | ||
| 484666 | CANLF07301 | |||
| 520497 | BOVIN17405 | |||
| 700481 | MACMU30434 | |||
| 733253 | Xenbase:XB-GENE-995813 | |||
| 791194 | ZFIN:ZDB-GENE-070112-932 | DANRE42140 | ||
| 854942 | SGD:S000004525 |
