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opioid related nociceptin receptor 1

Summary

Gene Symbol

OPRL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4987

PubChem

4987

Alliance of Genome Resources

HGNC:8155

Annotation

Keyword

3D-structure
Alternative splicing
Behavior
Cell membrane
Cytoplasmic vesicle
Disulfide bond
G-protein coupled receptor
Glycoprotein
Lipoprotein
Palmitate
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8IXB0	Kappa-type 3 opioid receptor Orphanin FQ receptor
P41146	Kappa-type 3 opioid receptor Orphanin FQ receptor
A0A5F9ZI64	Kappa-type 3 opioid receptor Orphanin FQ receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	12568343 8137918
phospholipase C-activating G protein-coupled receptor signaling pathway	IPI	10571060
neuropeptide signaling pathway	IBA
sensory perception	TAS	7566152
sensory perception of pain	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

reproductive process [inference]

multicellular organismal reproductive process [inference]

ovulation cycle [inference]

estrous cycle

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

regulation of urine volume [inference]

positive regulation of urine volume

nervous system process [inference]

sensory perception

sensory perception of pain

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

conditioned place preference

feeding behavior [inference]

eating behavior

rhythmic process [inference]

ovulation cycle [inference]

estrous cycle

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to estradiol

response to lipid [inference]

response to estradiol

response to oxygen-containing compound [inference]

response to estradiol

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of circadian rhythm [inference]

regulation of locomotor rhythm

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of intracellular signal transduction [inference]

regulation of cAMP-mediated signaling [inference]

negative regulation of cAMP-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of cAMP-mediated signaling

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

regulation of locomotor rhythm

regulation of biological quality [inference]

regulation of blood pressure [inference]

negative regulation of blood pressure

regulation of body fluid levels [inference]

regulation of urine volume [inference]

positive regulation of urine volume

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	12568343 8137918
plasma membrane	IBA
cytoplasmic vesicle	IEA
neuron projection	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nociceptin receptor activity	IDA	10571060 12568343
nociceptin receptor activity	IBA
G protein-coupled receptor activity	IMP	8137918
G protein-coupled receptor activity	IPI	10571060
protein binding	IPI	23597562 28298427 33961781

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

neuropeptide binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

nociceptin receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled opioid receptor activity [inference]

nociceptin receptor activity

G protein-coupled peptide receptor activity [inference]

nociceptin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
neuropeptide binding
neuropeptide signaling pathway

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Ortholog

Displaying entries **91 - 95** of 95 in total

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Species	Gene ID	Orthologous MAtrix
Chelonoidis abingdonii	116816854	CHEAB01986
Rhinolophus ferrumequinum	117015614	RHIFE24011
Balaenoptera musculus	118881180	BALMU19988
Panthera leo	122215286	PANLE08323
Ursus americanus	123790081	URSAM15968