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origin recognition complex subunit 1

Summary

Gene Symbol

ORC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

4998

PubChem

4998

Alliance of Genome Resources

HGNC:8487

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
DNA replication
DNA-binding
Disease variant
Dwarfism
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z8H0
Q13415	Replication control protein 1
Q96F82

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitotic DNA replication checkpoint signaling	IBA
DNA replication initiation	IBA IDA	16549788

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

cell cycle process [inference]

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication initiation

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

DNA integrity checkpoint signaling [inference]

DNA replication checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic DNA integrity checkpoint signaling [inference]

mitotic DNA replication checkpoint signaling

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic G2/M transition checkpoint [inference]

mitotic DNA replication checkpoint signaling

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

origin recognition complex

nuclear origin of replication recognition complex

nuclear protein-containing complex [inference]

nuclear origin of replication recognition complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **6 - 7** of 7 in total

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2
GO Term	Evidence Code	PMID
DNA replication origin binding	IBA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ORIGIN RECOGNITION COMPLEX SUBUNIT 1

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ATP binding
DNA replication origin binding

Displaying **all 3** entries
InterPro
AAA lid domain
AAA+ ATPase domain
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080512	Meier-Gorlin syndrome 1	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 82 in total

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Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18392		MGI:1328337	MOUSE40054
Drosophila melanogaster	35686		FB:FBgn0286788
Caenorhabditis elegans	176486		WB:WBGene00012650
Rattus norvegicus	313479		RGD:631435	RATNO32397
Xenopus laevis	398063		Xenbase:XB-GENE-998003
Pan troglodytes	456857	9598_0:00028a		PANTR21094
Bos taurus	513523			BOVIN26940
Danio rerio	554509		ZFIN:ZDB-GENE-030131-6960	DANRE38710
Macaca mulatta	713271			MACMU23135
Xenopus tropicalis	734048		Xenbase:XB-GENE-997997

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Last updated: December 9, 2024