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Submissions

prolyl 4-hydroxylase subunit beta

Summary

Gene Symbol

P4HB

Organism

Homo sapiens (human)

External Links

NCBI Gene

5034

PubChem

5034

Alliance of Genome Resources

HGNC:8548

JoGo

P4HB

TogoVar

P4HB

Annotation

Keyword

3D-structure
Acetylation
Cell membrane
Chaperone
Craniosynostosis
Direct protein sequencing
Disease variant
Disulfide bond
Endoplasmic reticulum
Isomerase
Osteogenesis imperfecta
Phosphoprotein
Proteomics identification
Redox-active center
Reference proteome
Repeat
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A024R8S5
P07237	Cellular thyroid hormone-binding protein Prolyl 4-hydroxylase subunit beta p55

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
protein folding	IBA
endoplasmic reticulum to Golgi vesicle-mediated transport	IEA
peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IDA	7753822
insulin processing	TAS
protein folding in endoplasmic reticulum	IDA	21091435

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

insulin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

insulin processing

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

insulin metabolic process [inference]

insulin processing

hormone metabolic process [inference]

peptide hormone processing [inference]

insulin processing

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

heterocycle metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

primary metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

insulin metabolic process [inference]

insulin processing

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

insulin metabolic process [inference]

insulin processing

macromolecule modification [inference]

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

organic cyclic compound metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing [inference]

insulin processing

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

protein modification process [inference]

protein hydroxylation [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

peptidyl-amino acid modification [inference]

peptidyl-proline modification [inference]

peptidyl-proline hydroxylation [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

insulin metabolic process [inference]

insulin processing

cellular process [inference]

protein folding

protein folding in endoplasmic reticulum

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

alpha-amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular modified amino acid metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

heterocycle metabolic process [inference]

4-hydroxyproline metabolic process [inference]

peptidyl-proline hydroxylation to 4-hydroxy-L-proline

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to stress [inference]

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

response to interleukin-7 [inference]

cellular response to interleukin-7

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-7

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

establishment of localization in cell [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cellular process [inference]

positive regulation of cell adhesion

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

regulation of substrate adhesion-dependent cell spreading [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of cell adhesion

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of apoptotic signaling pathway [inference]

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell adhesion

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing [inference]

insulin processing

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
extracellular region	NAS	14718574
endoplasmic reticulum	IDA	12095988 23152784 23475612 24415753 32149426
endoplasmic reticulum	IBA
endoplasmic reticulum lumen	TAS
endoplasmic reticulum-Golgi intermediate compartment	IDA

GO Hierarchy

cellular component

protein-containing complex

endoplasmic reticulum protein-containing complex [inference]

catalytic complex [inference]

oxidoreductase complex [inference]

procollagen-proline 4-dioxygenase complex

cellular anatomical entity [inference]

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
protein disulfide isomerase activity	EXP	15720785
protein disulfide isomerase activity	IDA	15225124 21091435 32149426
protein disulfide isomerase activity	IBA
actin binding	IPI	24415753

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [inference]

thiol oxidase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing S-S bonds [inference]

protein disulfide isomerase activity

catalytic activity, acting on a protein [inference]

peptidyl-proline dioxygenase activity [inference]

procollagen-proline dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

peptidyl-proline 4-dioxygenase activity [inference]

procollagen-proline 4-dioxygenase activity

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

cytoskeletal protein binding [inference]

actin binding

enzyme binding

protein dimerization activity [inference]

protein heterodimerization activity

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Disulfide isomerase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
isomerase activity
response to endoplasmic reticulum stress

Displaying **all 5** entries
InterPro
Protein disulfide-isomerase, thioredoxin-like domain
Protein disulphide isomerase
Thioredoxin domain
Thioredoxin, conserved site
Thioredoxin-like superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060438	Cole-Carpenter syndrome	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements