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SNF2 related chromatin remodeling annealing helicase 1

Summary

Gene Symbol

SMARCAL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

50485

PubChem

50485

Alliance of Genome Resources

HGNC:11102

JoGo

SMARCAL1

TogoVar

SMARCAL1

Annotation

Keyword

3D-structure
Acetylation
Coiled coil
Disease variant
Hydrolase
Isomerase
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NZC9	HepA-related protein SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 Sucrose nonfermenting protein 2-like 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
DNA repair	IBA
double-strand break repair via nonhomologous end joining	IMP	26089390
regulation of transcription by RNA polymerase II	IMP	18974355
DNA damage response	IMP	19793862
cellular response to DNA damage stimulus	IMP	19793862

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

formation of extrachromosomal circular DNA [inference]

t-circle formation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

double-strand break repair [inference]

double-strand break repair via nonhomologous end joining

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IDA	18974355
nucleoplasm	IDA
DNA replication factor A complex	IDA	19793862 19793863
site of double-strand break	IDA	19793862 19793863
nuclear replication fork	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

DNA replication factor A complex

cellular anatomical entity [inference]

nucleoplasm

replication fork [inference]

nuclear replication fork

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

site of DNA damage [inference]

site of double-strand break

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
helicase activity	IEA
protein binding	IPI	19793862 19793863 24126761 24910198 24981860
ATP binding	IEA
ATP-dependent activity, acting on DNA
hydrolase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

single-stranded DNA binding [inference]

DNA/DNA annealing activity [inference]

ATP-dependent DNA/DNA annealing activity

annealing activity [inference]

DNA/DNA annealing activity [inference]

ATP-dependent DNA/DNA annealing activity

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

helicase

Functional Category

H: Coenzyme transport and metabolism
L: Replication, recombination and repair
V: Defense mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
DNA repair
hydrolase activity
nucleotide binding

Displaying **all 7** entries
InterPro
HARP domain
Helicase superfamily 1/2, ATP-binding domain
Helicase, C-terminal domain-like
P-loop containing nucleoside triphosphate hydrolase
SNF2, N-terminal
SNF2-like, N-terminal domain superfamily
SNF2/RAD5-like, C-terminal helicase domain