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Guidelines

MIRAGE

NADPH oxidase 3

Summary

Gene Symbol

NOX3

Organism

Homo sapiens (human)

External Links

NCBI Gene

50508

PubChem

50508

Alliance of Genome Resources

HGNC:7890

Annotation

Keyword

Cell membrane
Glycoprotein
Heme
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9HBY0	Mitogenic oxidase 2 gp91phox homolog 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
temperature homeostasis	IEA
defense response	IBA
detection of gravity	IEA
superoxide anion generation	IBA
otolith development	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

cellular process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

developmental process [inference]

anatomical structure development [inference]

otolith development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

response to stimulus [inference]

response to stress [inference]

defense response

response to external stimulus [inference]

detection of external stimulus [inference]

detection of gravity

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of gravity

response to gravity [inference]

detection of gravity

detection of stimulus [inference]

detection of external stimulus [inference]

detection of gravity

detection of abiotic stimulus [inference]

detection of gravity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
plasma membrane	ISS
plasma membrane	TAS
plasma membrane	IBA
NADPH oxidase complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	15824103 32296183
superoxide-generating NAD(P)H oxidase activity	IDA	15181005 15824103
superoxide-generating NAD(P)H oxidase activity	IBA
heme binding	ISS
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

superoxide-generating NAD(P)H oxidase activity

superoxide-generating NADPH oxidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nadph oxidase

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
calcium ion binding
oxidoreductase activity
superoxide anion generation
superoxide-generating NAD(P)H oxidase activity

Displaying **all 6** entries
InterPro
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Riboflavin synthase-like beta-barrel

Ortholog

Displaying entries **31 - 40** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mustela putorius furo	101686368		MUSPF02374
Ficedula albicollis	101805975		FICAL00152
Melopsittacus undulatus	101881590		MELUD05108
Chrysemys picta bellii	101942294		CHRPI34251
Ictidomys tridecemlineatus	101956347		ICTTR18428
Chinchilla lanigera	102019435		CHILA10743
Macaca fascicularis	102132902		MACFA31541
Capra hircus	102177632		CAPHI30427
Latimeria chalumnae	102358274		LATCH04569
Myotis lucifugus	102419413		MYOLU08217

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025