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Guidelines

MIRAGE

intersectin 2

Summary

Gene Symbol

ITSN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

50618

PubChem

50618

Alliance of Genome Resources

HGNC:6184

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Coiled coil
Cytoplasm
Differentiation
Endocytosis
Host-virus interaction
Metal-binding
Phosphoprotein
Reference proteome
Repeat
SH3 domain

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9NZM3	SH3 domain-containing protein 1B SH3P18 SH3P18-like WASP-associated protein
A6H8W8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endosomal transport	IBA
cell differentiation	IEA
clathrin-dependent synaptic vesicle endocytosis	IBA
positive regulation of dendrite extension	IDA	23999003

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent synaptic vesicle endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis [inference]

clathrin-dependent synaptic vesicle endocytosis

endosomal transport

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis [inference]

clathrin-dependent synaptic vesicle endocytosis

cellular developmental process [inference]

cell differentiation

cellular localization [inference]

intracellular transport [inference]

developmental process [inference]

cellular developmental process [inference]

cell differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent synaptic vesicle endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis [inference]

clathrin-dependent synaptic vesicle endocytosis

endosomal transport

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis [inference]

clathrin-dependent synaptic vesicle endocytosis

intracellular transport [inference]

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent synaptic vesicle endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis [inference]

clathrin-dependent synaptic vesicle endocytosis

establishment of localization in cell [inference]

intracellular transport [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis [inference]

clathrin-dependent synaptic vesicle endocytosis

cellular localization [inference]

intracellular transport [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
centrosome	IDA	20479469
cytosol	TAS
plasma membrane	IBA
presynaptic membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

microtubule organizing center [inference]

centrosome

cytosol

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	IEA
calcium ion binding	IEA
protein binding	IPI	17696407 24658140 31980649 33961781 35271311 35384245
molecular adaptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

intersectin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	16443	FB:FBgn0023388
Mus musculus	20403		MOUSE09622
Xenopus tropicalis	50618	Xenbase:XB-GENE-1012238
Rattus norvegicus	313934		RATNO35753
Danio rerio	445153		DANRE12427
Pan troglodytes	459066		PANTR27161
Canis lupus familiaris	475683		CANLF04936
Macaca mulatta	704858		MACMU07653
Caenorhabditis elegans	854822	WB:WBGene00006405
Equus caballus	100056119		HORSE09904

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Last updated: April 7, 2025