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Guidelines

MIRAGE

gem nuclear organelle associated protein 4

Summary

Gene Symbol

GEMIN4

Organism

Homo sapiens (human)

External Links

NCBI Gene

50628

PubChem

50628

Alliance of Genome Resources

HGNC:15717

Annotation

Keyword

Acetylation
Cytoplasm
Disease variant
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
mRNA splicing

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P57678	Component of gems 4 p97
Q8WUM5
I3L2C7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
spliceosomal snRNP assembly	EXP	12067652
spliceosomal snRNP assembly	IDA	18984161
spliceosomal snRNP assembly	IBA
rRNA processing	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

ncRNA processing [inference]

rRNA processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

ncRNA processing [inference]

rRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

ncRNA processing [inference]

rRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

ncRNA processing [inference]

rRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

ncRNA processing [inference]

rRNA processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

ncRNA processing [inference]

rRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

ncRNA processing [inference]

rRNA processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

ncRNA processing [inference]

rRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

ncRNA processing [inference]

rRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

rRNA processing

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA processing

ncRNA processing [inference]

rRNA processing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal snRNP assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal snRNP assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

spliceosomal snRNP assembly

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
nucleoplasm	TAS
nucleolus	IDA	10725331
cytoplasm	TAS	10725331
cytosol	TAS
cytosol	IDA	18984161 20513430

GO Hierarchy

cellular component

protein-containing complex [inference]

Sm-like protein family complex [inference]

nuclear protein-containing complex [inference]

small nuclear ribonucleoprotein complex

ribonucleoprotein complex [inference]

small nuclear ribonucleoprotein complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11714716 12869526 17178713 19750007 21988832 23752268 28514442 32296183 33961781
ribonucleoprotein complex binding	IDA	10725331

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Gem-associated protein 4

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
spliceosomal snRNP assembly

Displaying 1 entry
InterPro
Gem-associated protein 4

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:0081263	neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	50628	Xenbase:XB-GENE-1001764
Xenopus tropicalis	54664	Xenbase:XB-GENE-5843726
Xenopus tropicalis	71900	Xenbase:XB-GENE-5843726
Mus musculus	276919		MOUSE03569
Xenopus tropicalis	312132	Xenbase:XB-GENE-5843726
Danio rerio	324754		DANRE08191
Pan troglodytes	454403		PANTR13150
Bos taurus	539147		BOVIN12470
Macaca mulatta	699841		MACMU14026
Monodelphis domestica	100011980		MONDO14761

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Supported by JST NBDC Grant Number JPMJND2204

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025