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Guidelines

MIRAGE

peptidylglycine alpha-amidating monooxygenase

Summary

Gene Symbol

PAM

Organism

Homo sapiens (human)

External Links

NCBI Gene

5066

PubChem

5066

Alliance of Genome Resources

HGNC:8596

Annotation

Keyword

Alternative splicing
Calcium
Cleavage on pair of basic residues
Copper
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Lipid metabolism
Lyase
Metal-binding
Monooxygenase
Multifunctional enzyme
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Secreted
Signal
Sulfation
Transmembrane helix
Vitamin C
Zinc

Proteins

Displaying **all 6** entries
UniProt	Protein Name
A0A804HIQ0
A0A8C8KD64
O43832
P19021
A0A804HKV8
A0A804HKM7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peptide amidation	IDA	12699694 2357221
peptide metabolic process
response to zinc ion	IDA	12699694
fatty acid primary amide biosynthetic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

amide metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process

peptide modification [inference]

peptide amidation

fatty acid primary amide metabolic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

fatty acid primary amide biosynthetic process

organonitrogen compound biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

fatty acid primary amide biosynthetic process

response to stimulus [inference]

response to chemical [inference]

response to inorganic substance [inference]

response to metal ion [inference]

response to zinc ion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	IBA
membrane	HDA	19946888
transport vesicle membrane	IEA
secretory granule membrane	ISS
extracellular exosome	HDA	19199708 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

bounding membrane of organelle [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
peptidylglycine monooxygenase activity	IDA	12699694 2357221
peptidylglycine monooxygenase activity	IBA
peptidylamidoglycolate lyase activity	ISS
peptidylamidoglycolate lyase activity	IDA	12699694
copper ion binding	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

peptidylglycine monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

peptidylglycine monooxygenase activity

carbon-nitrogen lyase activity [inference]

amidine-lyase activity [inference]

peptidylamidoglycolate lyase activity

catalytic activity, acting on a protein [inference]

peptidylamidoglycolate lyase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Peptidyl-glycine alpha-amidating monooxygenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
catalytic activity
copper ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen
peptide metabolic process
peptidylglycine monooxygenase activity

Displaying **all 8** entries
InterPro
Copper type II ascorbate-dependent monooxygenase, C-terminal
Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
Copper type II, ascorbate-dependent monooxygenase, N-terminal
Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
NHL repeat
PHM/PNGase F domain superfamily
Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyase
Six-bladed beta-propeller, TolB-like

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025