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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
phosphoenolpyruvate carboxykinase 2, mitochondrial
Summary
- Gene Symbol
-
- PCK2
- Aliases
-
- PEPCK
- PEPCK2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Acetylation
- Alternative splicing
- Decarboxylase
- Disease variant
- GTP-binding
- Gluconeogenesis
- Kinase
- Manganese
- Metal-binding
- Mitochondrion
- Phosphoprotein
- Pyruvate
- Reference proteome
- Transit peptide
- Proteins
| UniProt | Protein Name |
|---|---|
| Q16822 |
|
| A0A384MTT2 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of insulin secretion | ||
| cellular response to glucose stimulus | ||
| gluconeogenesis |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular metabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytosol |
|
|
| mitochondrial matrix | ||
| mitochondrion |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| GTP binding | ||
| phosphoenolpyruvate carboxykinase activity | ||
| phosphoenolpyruvate carboxykinase (GTP) activity | ||
| manganese ion binding | ||
| protein binding |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:3649 | pyruvate decarboxylase deficiency | |
| DOID:3651 | pyruvate carboxylase deficiency disease | |
| DOID:3683 | lung benign neoplasm | |
| DOID:374 | nutrition disease | |
| DOID:3904 | bronchus carcinoma | |
| DOID:3905 | lung carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:4195 | hyperglycemia | |
| DOID:4766 | embryoma | |
| DOID:684 | hepatocellular carcinoma |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000799 | Renal steatosis |
| HP:0001397 | Hepatic steatosis |
| HP:0001399 | Hepatic failure |
| HP:0001943 | Hypoglycemia |
| HP:0005959 | Impaired gluconeogenesis |
| Disease ID | Disease Name |
|---|---|
| OMIM:261650 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 113448778 | PSETE22494 | ||
| 100088404 | ORNAN04992 | ||
| 100927720 | SARHA01830 | ||
| 100404441 | CALJA00918 | ||
| 105600256 | CERAT40107 | ||
| 102135856 | MACFA38886 | ||
| 714922 | MACMU41943 | ||
| 105477850 | MACNE17497 | ||
| 101014172 | PAPAN37800 | ||
| 105532712 | MANLE36539 |
