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protein-L-isoaspartate (D-aspartate) O-methyltransferase

Summary

Gene Symbol

PCMT1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5110

PubChem

5110

Alliance of Genome Resources

HGNC:8728

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Methyltransferase
Proteomics identification
Reference proteome
S-adenosyl-L-methionine

Proteins

Displaying **all 4** entries
UniProt	Protein Name
F6S8N6	L-isoaspartyl protein carboxyl methyltransferase Protein L-isoaspartyl/D-aspartyl methyltransferase Protein-beta-aspartate methyltransferase
B7Z972
A0A3F2YNX8
P22061	L-isoaspartyl protein carboxyl methyltransferase Protein L-isoaspartyl/D-aspartyl methyltransferase Protein-beta-aspartate methyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein methylation	IDA	3167043
protein repair	TAS	8074695

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein repair

protein modification process [inference]

protein alkylation [inference]

protein methylation

methylation [inference]

macromolecule methylation [inference]

protein methylation

primary metabolic process [inference]

protein metabolic process [inference]

protein repair

protein modification process [inference]

protein alkylation [inference]

protein methylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein repair

protein modification process [inference]

protein alkylation [inference]

protein methylation

macromolecule modification [inference]

protein modification process [inference]

protein alkylation [inference]

protein methylation

macromolecule methylation [inference]

protein methylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein repair

protein modification process [inference]

protein alkylation [inference]

protein methylation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular vesicle	HDA	24769233
cytosol	IDA TAS
cytoplasm	IBA
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 28514442 32296183 32814053 32838362 33961781 34232536
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IBA IDA TAS	3167043 8074695
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

O-methyltransferase activity [inference]

carboxyl-O-methyltransferase activity [inference]

protein carboxyl O-methyltransferase activity [inference]

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

protein methyltransferase activity [inference]

protein carboxyl O-methyltransferase activity [inference]

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

catalytic activity, acting on a protein [inference]

protein methyltransferase activity [inference]

protein carboxyl O-methyltransferase activity [inference]

protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

binding [inference]

protein binding

cell adhesion molecule binding [inference]

cadherin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE

Functional Category

I: Lipid transport and metabolism
K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
methylation
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:3069	malignant astrocytoma	Alliance of Genome Resources
DOID:3070	high grade glioma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18537		MGI:97502	MOUSE01654
Rattus norvegicus	25604		RGD:3268	RATNO16564
Danio rerio	30751		ZFIN:ZDB-GENE-990415-134	DANRE19184
Drosophila melanogaster	40668		FB:FBgn0086768
Caenorhabditis elegans	178981		WB:WBGene00003954
Pan troglodytes	463062	9598_0:001f53		PANTR39286
Canis lupus familiaris	476242			CANLF00200
Xenopus laevis	495685		Xenbase:XB-GENE-959022
Xenopus tropicalis	595004		Xenbase:XB-GENE-959017
Bos taurus	613854			BOVIN35965

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OrthoDB (Group)

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Acknowledgements