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dynein cytoplasmic 1 light intermediate chain 1

Summary

Gene Symbol

DYNC1LI1

Organism

Homo sapiens (human)

External Links

NCBI Gene

51143

PubChem

51143

Alliance of Genome Resources

HGNC:18745

Annotation

Keyword

3D-structure
ATP-binding
Centromere
Chromosome
Cytoskeleton
Dynein
Endosome
Host-virus interaction
Kinetochore
Membrane
Microtubule
Mitosis
Motor protein
Phosphoprotein
Proteomics identification
Reference proteome
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E9PHI6
Q9Y6G9	Dynein light chain A Dynein light intermediate chain 1, cytosolic

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
early endosome to recycling endosome transport	IDA	20026645

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to recycling endosome transport

cell division

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to recycling endosome transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to recycling endosome transport

intracellular transport [inference]

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to recycling endosome transport

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to recycling endosome transport

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to recycling endosome transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of intracellular signal transduction [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of chromosome organization [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cell cycle process [inference]

regulation of mitotic nuclear division [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of chromosome segregation [inference]

regulation of sister chromatid segregation [inference]

regulation of mitotic sister chromatid segregation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of chromosome separation [inference]

regulation of mitotic sister chromatid separation [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle process [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of cell cycle phase transition [inference]

regulation of cell cycle checkpoint [inference]

regulation of spindle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic spindle checkpoint [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle checkpoint [inference]

positive regulation of spindle checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

regulation of mitotic cell cycle spindle assembly checkpoint [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic cell cycle spindle assembly checkpoint

regulation of vesicle-mediated transport

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
spindle pole	IDA	19229290
cytoplasmic dynein complex	IBA IDA	19229290 25272277
recycling endosome membrane	IEA
centrosome	IDA	21399614

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

dynein complex [inference]

cytoplasmic dynein complex

catalytic complex [inference]

dynein complex [inference]

cytoplasmic dynein complex

cellular anatomical entity [inference]

spindle pole

microtubule organizing center [inference]

centrosome

cytosol

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

recycling endosome membrane

endocytic vesicle membrane

secretory granule membrane

ficolin-1-rich granule membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

recycling endosome membrane

endocytic vesicle membrane

secretory granule membrane

ficolin-1-rich granule membrane

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

kinetochore

supramolecular complex [inference]

kinetochore

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674
dynein heavy chain binding	IBA IPI	25272277
GTP binding	IDA	25272277

GO Hierarchy

molecular function

binding [inference]

protein binding

dynein heavy chain binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

GDP binding

purine ribonucleoside triphosphate binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

molecular adaptor activity

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dynein light intermediate chain

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
dynein heavy chain binding
microtubule cytoskeleton organization
microtubule-based movement
nucleotide binding

Displaying **all 3** entries
InterPro
Dynein 1 light intermediate chain
Dynein family light intermediate chain
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	32057		FB:FBgn0030276
Caenorhabditis elegans	178260		WB:WBGene00001007
Mus musculus	235661		MGI:2135610	MOUSE63823
Rattus norvegicus	252902		RGD:71072	RATNO41497
Xenopus laevis	379847		Xenbase:XB-GENE-6254682
Xenopus laevis	398202		Xenbase:XB-GENE-865944
Pan troglodytes	460251	9598_0:001365		PANTR30692
Canis lupus familiaris	477038			CANLF09006
Bos taurus	510330			BOVIN17199
Danio rerio	556103		ZFIN:ZDB-GENE-030131-4108	DANRE15995

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Last updated: December 9, 2024