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cytochrome b5 reductase 4

Summary

Gene Symbol

CYB5R4

Aliases

b5+b5R
dJ676J13.1

Organism

Homo sapiens (human)

External Links

NCBI Gene

51167

HGNC

20147

KEGG Gene ID

hsa:51167

PubChem

51167

Alliance of Genome Resources

HGNC:20147

Annotation

Keyword

3D-structure
Acetylation
Endoplasmic reticulum
FAD
Heme
NAD
Oxidoreductase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7L1T6	Flavohemoprotein b5/b5R N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein cb5/cb5R

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
response to antibiotic	ISS
reactive oxygen species metabolic process	IDA	15131110
bicarbonate transport
superoxide metabolic process	IBA IDA	10611283
detection of oxygen		10611283

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process

superoxide metabolic process

cellular process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process

superoxide metabolic process

cellular developmental process [inference]

cell development

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

developmental process [inference]

anatomical structure development [inference]

cell development

cellular developmental process [inference]

cell development

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to oxygen levels [inference]

detection of oxygen

response to chemical [inference]

response to antibiotic

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of oxygen

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

organic anion transport [inference]

bicarbonate transport

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

one-carbon compound transport [inference]

bicarbonate transport

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane
endoplasmic reticulum	IBA IDA	15131110
perinuclear region of cytoplasm	IDA	10611283
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

perinuclear region of cytoplasm

Displaying **all 5** entries
GO Term	Evidence Code	PMID
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	IDA	15131110
metal ion binding	IEA
heme binding	IBA
NAD(P)H oxidase H2O2-forming activity	IDA	10611283 15131110
cytochrome-b5 reductase activity, acting on NAD(P)H	IBA IDA TAS	10611283

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

cytochrome-b5 reductase activity, acting on NAD(P)H

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

NAD(P)H oxidase H2O2-forming activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome b5

Functional Category

C: Energy production and conversion
H: Coenzyme transport and metabolism
I: Lipid transport and metabolism

Displaying **all 5** entries
Gene Ontology
cytochrome-b5 reductase activity, acting on NAD(P)H
generation of precursor metabolites and energy
heme binding
metal ion binding
superoxide metabolic process

Displaying **all 3** entries
InterPro
Cytochrome b5, heme-binding site
Cytochrome b5-like heme/steroid binding domain superfamily
Cytochrome b5-like heme/steroid binding domain

Human Protein Atlas

ENSG00000065615

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)