GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Golgi apparatus
Hydrolase
Reference proteome
Signal
Transmembrane helix
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UK23	Mannose 6-phosphate-uncovering enzyme Phosphodiester alpha-GlcNAcase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	TAS	10551838
secretion of lysosomal enzymes	IBA
protein targeting to lysosome	TAS	10551838
protein modification process	TAS	10551838
lysosome organization	TAS	10551838

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

protein glycosylation

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

protein modification process

protein glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process

protein glycosylation

macromolecule modification [inference]

protein modification process

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

protein glycosylation

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

secretion of lysosomal enzymes

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion [inference]

secretion of lysosomal enzymes

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein transport [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

secretion of lysosomal enzymes

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	TAS	10551838
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

Golgi cisterna membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	26544806
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hexosaminidase activity [inference]

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000103174

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:24372

H₂O

H⁺ + N-acetyl-D-glucosamine

Enzyme

3.1.4.45

PMID

6263889

Disease

Disease Ontology

Displaying entries **1 - 10** of 12 in total

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DO ID	Disease Name	Source
DOID:0060243	stuttering	DisGeNET
DOID:0060357	chylomicron retention disease	DisGeNET
DOID:0080070	mucolipidosis II alpha/beta	DisGeNET
DOID:0080071	mucolipidosis III alpha/beta	DisGeNET
DOID:0111394	mucopolysaccharidosis type IIIB	DisGeNET
DOID:12801	mucopolysaccharidosis III	DisGeNET
DOID:1289	neurodegenerative disease	DisGeNET
DOID:13417	alexia	DisGeNET DisGeNET
DOID:14499	Fabry disease	DisGeNET
DOID:3343	glycoproteinosis	DisGeNET DisGeNET

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Latimeria chalumnae	102354196		LATCH04362
Danio rerio	569719	ZFIN:ZDB-GENE-070928-4	DANRE10913
Astyanax mexicanus	103029606		ASTMX13910
Ictalurus punctatus	108270758		ICTPU14426
Electrophorus electricus	113573175		ELEEL03624
Salmo salar	106605373		SALSA121950
Salmo trutta	115179583		SALTR43537
Gadus morhua	115553571		GADMO04003
Oreochromis niloticus	100693112		ORENI05357
Sparus aurata	115566949		SPAAU58441

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Acknowledgements