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hydroxyacid oxidase 2

Summary

Gene Symbol

HAO2

Aliases

(S)-2-hydroxy-acid oxidase
GIG16
HAOX2
glycolate oxidase
growth-inhibiting protein 16
long-chain L-2-hydroxy acid oxidase

Organism

Homo sapiens (human)

External Links

NCBI Gene

51179

HGNC

4810

KEGG Gene ID

hsa:51179

PubChem

51179

Alliance of Genome Resources

HGNC:4810

Annotation

Keyword

Alternative splicing
FMN
Fatty acid metabolism
Oxidoreductase
Peroxisome
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NYQ3	(S)-2-hydroxy-acid oxidase, peroxisomal Cell growth-inhibiting gene 16 protein Long chain alpha-hydroxy acid oxidase Long-chain L-2-hydroxy acid oxidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
fatty acid oxidation	IDA	10777549

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
peroxisomal matrix	TAS
peroxisomal matrix	IDA	10777549
peroxisomal matrix	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

Displaying **all 4** entries
GO Term	Evidence Code	PMID
(S)-2-hydroxy-acid oxidase activity	IDA	10777549
(S)-2-hydroxy-acid oxidase activity	IBA
protein binding	IPI	32296183
FMN binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [inference]

(S)-2-hydroxy-acid oxidase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

ribonucleotide binding [inference]

FMN binding

ion binding [inference]

anion binding [inference]

FMN binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

ribonucleotide binding [inference]

FMN binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

FMN binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

(S)-2-hydroxy-acid oxidase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism

Displaying **all 2** entries
Gene Ontology
FMN binding
oxidoreductase activity

Displaying **all 5** entries
InterPro
Aldolase-type TIM barrel
Alpha-hydroxy acid dehydrogenase, FMN-dependent
FMN hydroxy acid dehydrogenase domain
FMN-dependent alpha-hydroxy acid dehydrogenase, active site
FMN-dependent dehydrogenase

KEGG BRITE Database

Orthology

K11517

Name

(S)-2-hydroxy-acid oxidase [EC:1.1.3.15]

References

10777549

Rhea

RHEA:16789

O₂ + a (2S)-2-hydroxycarboxylate

H₂O₂ + a 2-oxocarboxylate

Enzyme

1.1.3.15

PMID

RHEA:25311

O₂ + glycolate

H₂O₂ + glyoxylate

Enzyme

1.1.3.15

PMID

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	51179	Xenbase:XB-GENE-979509
Saccharomyces cerevisiae S288C	54363	SGD:S000004518
Mus musculus	56185		MOUSE37792
Rattus norvegicus	84029		RATNO24319
Danio rerio	393455		DANRE43992
Pan troglodytes	457163		PANTR21878
Canis lupus familiaris	475814		CANLF05308
Bos taurus	509481		BOVIN26140
Macaca mulatta	712615		MACMU21789
Monodelphis domestica	100012628		MONDO14318

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Acknowledgements