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Guidelines

MIRAGE

translational activator of cytochrome c oxidase I

Summary

Gene Symbol

TACO1

Organism

Homo sapiens (human)

External Links

NCBI Gene

51204

PubChem

51204

Alliance of Genome Resources

HGNC:24316

Annotation

Keyword

Activator
Coiled coil
Leigh syndrome
Mitochondrion
Proteomics identification
Reference proteome
Translation regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BSH4	Coiled-coil domain-containing protein 44 Translational activator of mitochondrially-encoded cytochrome c oxidase I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrial cytochrome c oxidase assembly	IEA
motor learning	IEA
regulation of mitochondrial translation	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

respiratory chain complex IV assembly [inference]

mitochondrial cytochrome c oxidase assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial cytochrome c oxidase assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

respiratory chain complex IV assembly [inference]

mitochondrial cytochrome c oxidase assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial cytochrome c oxidase assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

motor learning

behavior [inference]

learning or memory [inference]

learning [inference]

motor learning

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of mitochondrial gene expression [inference]

regulation of mitochondrial translation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of mitochondrial gene expression [inference]

regulation of mitochondrial translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of mitochondrial gene expression [inference]

regulation of mitochondrial translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of mitochondrial gene expression [inference]

regulation of mitochondrial translation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	HTP	34800366

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mRNA binding	IEA
protein binding	IPI	16189514 32296183 32814053
rRNA binding	IEA
mitochondrial ribosome binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding [inference]

mitochondrial ribosome binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transcriptional regulatory protein

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 6** entries
InterPro
Integrase-like, N-terminal
TACO1/YebC-like, N-terminal domain
TACO1/YebC-like, second and third domains
Transcriptional regulator TACO1-like, domain 3
Transcriptional regulator TACO1-like
YebC-like

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070495	mitochondrial complex IV deficiency nuclear type 8	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025