GlyCosmos Portal

GlyTouCan

Glycan Structure Repository

GlyComb

Glycoconjugate Repository

GlycoPOST

Glycomics MS raw data Repository

UniCarb-DR

Glycomics MS Repository for glycan annotations from GlycoWorkbench

LM-GlycoRepo

Repository for lectin-assisted multimodality data

All Resources

Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms

Other Information

Release Statistics Download

Tools

Glycan Converters

LM-GlycomeAtlas

Search Tools

Cross Search Glycan Search Publication Search Programmatic Access

proprotein convertase subtilisin/kexin type 1

Summary

Gene Symbol

PCSK1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5122

PubChem

5122

Alliance of Genome Resources

HGNC:8743

Annotation

Keyword

Alternative splicing
Calcium
Cleavage on pair of basic residues
Cytoplasmic vesicle
Disease variant
Disulfide bond
Glycoprotein
Obesity
Reference proteome
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P29120	Prohormone convertase 1 Proprotein convertase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

1

2

3

4

5

Next ›

Last »
GO Term	Evidence Code	PMID
insulin processing	IEA
proteolysis	TAS	9207799
response to glucose	IEA
positive regulation of protein secretion	IEA
response to calcium ion	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

amide biosynthetic process [inference]

peptide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

hormone metabolic process [inference]

peptide hormone processing

insulin processing

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

pancreas development

gland development [inference]

pituitary gland development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to fatty acid

response to cytokine [inference]

response to interleukin-1

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to chlorate

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to peptide [inference]

response to peptide hormone

response to salt [inference]

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

insulin processing

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
axon terminus	IEA
secretory granule lumen	TAS
membrane	IBA
perikaryon	IEA
neuron projection	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

neuron projection terminus [inference]

axon terminus

perinuclear region of cytoplasm

presynapse [inference]

axon terminus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
identical protein binding	IEA
serine-type endopeptidase activity	IBA ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

FURIN

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 8** entries
InterPro
Galactose-binding-like domain superfamily
Kexin/furin catalytic domain
P domain
Peptidase S8, subtilisin, His-active site
Peptidase S8, subtilisin, Ser-active site
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0111698	proprotein convertase 1/3 deficiency	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:1799	islet cell tumor	Alliance of Genome Resources
DOID:28	endocrine system disease	Alliance of Genome Resources
DOID:4195	hyperglycemia	Alliance of Genome Resources
DOID:7998	hyperthyroidism	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 87 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18548		MGI:97511	MOUSE10990
Rattus norvegicus	25204		RGD:3272	RATNO22893
Bos taurus	281967			BOVIN34004
Ovis aries	443029			SHEEP17060
Pan troglodytes	461740			PANTR35094
Canis lupus familiaris	479149			CANLF11868
Macaca mulatta	699742			MACMU39193
Saccharomyces cerevisiae S288C	855483		SGD:S000005182
Danio rerio	100005716		ZFIN:ZDB-GENE-071009-1	DANRE21674
Monodelphis domestica	100010673			MONDO18627

About Release Notes Help Feedback

Click here to visit the beta site.

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: support@glycosmos.org

GlyCosmos Portal v4.1.0

Last updated: December 9, 2024