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Guidelines

MIRAGE

proprotein convertase subtilisin/kexin type 1

Summary

Gene Symbol

PCSK1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5122

PubChem

5122

Alliance of Genome Resources

HGNC:8743

Annotation

Keyword

Alternative splicing
Calcium
Cleavage on pair of basic residues
Cytoplasmic vesicle
Disease variant
Disulfide bond
Glycoprotein
Obesity
Reference proteome
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P29120	Prohormone convertase 1 Proprotein convertase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
proteolysis	TAS	9207799
cell-cell signaling	TAS	9207799
response to xenobiotic stimulus	IEA
response to glucose	IEA
response to chlorate	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

amide biosynthetic process [inference]

peptide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

hormone metabolic process [inference]

peptide hormone processing

insulin processing

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

insulin processing

peptide biosynthetic process

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

pancreas development

gland development [inference]

pituitary gland development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to lipid [inference]

response to lipopolysaccharide

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid

response to fatty acid

response to cytokine [inference]

response to interleukin-1

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to chlorate

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to peptide [inference]

response to peptide hormone

response to salt [inference]

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

insulin processing

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	8397508
extracellular space	IBA
trans-Golgi network	IEA
membrane	IBA
transport vesicle	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

neuron projection terminus [inference]

axon terminus

perinuclear region of cytoplasm

presynapse [inference]

axon terminus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	ISS
serine-type endopeptidase activity	IBA
identical protein binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proprotein convertase subtilisin/kexin type

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 8** entries
InterPro
Galactose-binding-like domain superfamily
Kexin/furin catalytic domain
P domain
Peptidase S8, subtilisin, His-active site
Peptidase S8, subtilisin, Ser-active site
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111698	proprotein convertase 1/3 deficiency	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **104** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	5045	SGD:S000005182
Saccharomyces cerevisiae S288C	5046	SGD:S000005182
Xenopus tropicalis	5122	Xenbase:XB-GENE-983314
Saccharomyces cerevisiae S288C	5125	SGD:S000005182
Saccharomyces cerevisiae S288C	9159	SGD:S000005182
Mus musculus	18548	Xenbase:XB-GENE-983314	MOUSE10990
Saccharomyces cerevisiae S288C	18550	SGD:S000005182
Saccharomyces cerevisiae S288C	18551	SGD:S000005182
Saccharomyces cerevisiae S288C	18552	SGD:S000005182
Saccharomyces cerevisiae S288C	18553	SGD:S000005182

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Last updated: August 4, 2025