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shisa family member 5

Summary

Gene Symbol

SHISA5

Organism

Homo sapiens (human)

External Links

NCBI Gene

51246

PubChem

51246

Alliance of Genome Resources

HGNC:30376

Annotation

Keyword

Alternative splicing
Apoptosis
Endoplasmic reticulum
Nucleus
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N114	Putative NF-kappa-B-activating protein 120 Scotin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA
positive regulation of canonical NF-kappaB signal transduction	HMP	12761501

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nuclear membrane	IEA
endoplasmic reticulum membrane	IEA
endoplasmic reticulum lumen	TAS
endoplasmic reticulum	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15064722 17889823 32296183
WW domain binding	IPI	15064722

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding [inference]

WW domain binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein shisa-5

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
positive regulation of canonical NF-kappaB signal transduction

Displaying 1 entry
InterPro
Shisa family

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	66940		MGI:1915044	MOUSE62846
Rattus norvegicus	301013		RGD:1359661	RATNO41961
Pan troglodytes	460345	9598_0:0010da		PANTR31057
Danio rerio	558619		ZFIN:ZDB-GENE-030131-6596	DANRE23479
Danio rerio	558681		ZFIN:ZDB-GENE-050208-731
Danio rerio	558811		ZFIN:ZDB-GENE-050208-412
Bos taurus	616861			BOVIN17879
Macaca mulatta	709615			MACMU29258
Ornithorhynchus anatinus	100078119			ORNAN29342
Pongo abelii	100171854	9601_0:000f38		PONAB26276