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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
proprotein convertase subtilisin/kexin type 2
Summary
- Gene Symbol
-
- PCSK2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Cleavage on pair of basic residues
- Cytoplasmic vesicle
- Disulfide bond
- Glycoprotein
- Reference proteome
- Secreted
- Serine protease
- Signal
- Zymogen
- Proteins
| UniProt | Protein Name |
|---|---|
| P16519 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| insulin processing | ||
| proteolysis | ||
| protein autoprocessing | ||
| peptide hormone processing | ||
| nervous system development |
| GO Term | Evidence Code | PMID |
|---|---|---|
| membrane | ||
| secretory granule | ||
| perikaryon | ||
| intracellular membrane-bounded organelle | ||
| neuron projection |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| serine-type endopeptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- FURIN
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| hydrolase activity |
| peptide hormone processing |
| proteolysis |
| serine-type endopeptidase activity |
| serine-type peptidase activity |
Disease
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 18549 | MGI:97512 | MOUSE35600 | ||
| 25121 | RGD:3273 | RATNO26436 | ||
| 43215 | FB:FBgn0023179 | |||
| 179412 | WB:WBGene00001172 | |||
| 281968 | BOVIN04526 | |||
| 373675 | Xenbase:XB-GENE-960018 | |||
| 444586 | Xenbase:XB-GENE-17330431 | |||
| 445533 | PIGXX11301 | |||
| 458106 | 9598_0:005079 | PANTR24399 | ||
| 485757 | CANLF09277 |
