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bifunctional apoptosis regulator

Summary

Gene Symbol

BFAR

Organism

Homo sapiens (human)

External Links

NCBI Gene

51283

PubChem

51283

Alliance of Genome Resources

HGNC:17613

Annotation

Keyword

Alternative splicing
Apoptosis
Endoplasmic reticulum
Glycoprotein
Proteomics identification
Reference proteome
Transferase
Transmembrane helix
Ubl conjugation
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9NZS9	RING finger protein 47
H3BMP2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
protein polyubiquitination	IDA	21068390
ubiquitin-dependent protein catabolic process	IDA	21068390
apoptotic process	IEA
negative regulation of apoptotic process	IDA	10716992
proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	21068390

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

protein autoubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

protein autoubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

protein autoubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

protein autoubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

protein autoubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of IRE1-mediated unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of IRE1-mediated unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of IRE1-mediated unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of IRE1-mediated unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

regulation of IRE1-mediated unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum unfolded protein response [inference]

negative regulation of IRE1-mediated unfolded protein response

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	21068390
endoplasmic reticulum membrane	NAS	21068390
plasma membrane	NAS	10716992
membrane	IDA	10716992

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	21068390 32296183 32814053
zinc ion binding	IEA
protein-macromolecule adaptor activity	IDA	10716992
metal ion binding
ubiquitin protein ligase activity	IDA	21068390

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

enzyme binding [inference]

protease binding [inference]

caspase binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Bifunctional apoptosis regulator

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
metal ion binding
proteasome-mediated ubiquitin-dependent protein catabolic process

Displaying **all 5** entries
InterPro
Sterile alpha motif domain
Sterile alpha motif/pointed domain superfamily
Zinc finger, RING-type, conserved site
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type