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glucosaminyl (N-acetyl) transferase 4

Summary

Gene Symbol

GCNT4

Aliases

C2GNT3
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4
core 2 beta-1,6-N-acetylglucosaminyltransferase 3

Organism

Homo sapiens (human)

External Links

NCBI Gene

51301

GGDB ID

gg110

HGNC

17973

mRNA

NM_016591

map

5q12

Protein

NP_057675

OMIM

616782

KEGG Gene ID

hsa:51301

PubChem

51301

Alliance of Genome Resources

HGNC:17973

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
neutrophil homeostasis	IEA
inter-male aggressive behavior	IEA
carbohydrate metabolic process	TAS	10753916
protein O-linked glycosylation	TAS	10753916
O-glycan processing	TAS

GO Hierarchy

biological process

immune system process [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

hormone metabolic process [inference]

thyroid hormone metabolic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

O-glycan processing

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

multicellular organismal process [inference]

behavior [inference]

aggressive behavior [inference]

inter-male aggressive behavior

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

kidney morphogenesis

tissue morphogenesis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

leukocyte homeostasis [inference]

neutrophil homeostasis

myeloid cell homeostasis [inference]

neutrophil homeostasis

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	TAS
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	TAS	10753916
acetylglucosaminyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
transferase activity

Human Protein Atlas

ENSG00000176928

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg110

Gene Symbol

GCNT4

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G00031MO	Ser/Thr	G00033MO	Ser/Thr	10753916

Displaying **all 5** entries
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
UDP-GlcNAc	G00031MO	[alpha]-1-methylumbelliferyl	G00033MO	[alpha]-1-methylumbelliferyl	10753916
UDP-GlcNAc	G00031MO	[alpha]-1-p-nitrophenyl	G00033MO	[alpha]-1-p-nitrophenyl	10753916
UDP-GlcNAc	G00031MO	Ser/Thr	G00033MO	Ser/Thr	10753916
UDP-GlcNAc	G00031MO	[alpha]	G00033MO	[alpha]	10753916
UDP-GlcNAc	G00031MO	[alpha]-1-benzyl	G00033MO	[alpha]-1-benzyl	10753916

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Donor	Acceptor	Reducing terminal(Acceptor)	Reference
UDP-GlcNAc	G00049MO	Cer	10753916
UDP-GlcNAc	G57321FI		10753916
UDP-GlcNAc	G33476GF	[beta]-1-methyl	10753916
UDP-GlcNAc	G00035MO	[alpha]-1-p-nitrophenyl	10753916
UDP-GlcNAc	G58896AZ	Cer	10753916

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	XP_226703	XM_226703
Mus musculus	XP_138797	XM_138797

KEGG BRITE Database

Orthology

K09663

Name

beta-1,6-N-acetylglucosaminyltransferase 4 [EC:2.4.1.-]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05912	2.4.1.102	G00031MO	G00033MO

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	2650	WB:WBGene00001644
Caenorhabditis elegans	2651	WB:WBGene00001644
Caenorhabditis elegans	9245	WB:WBGene00001644
Caenorhabditis elegans	14537	WB:WBGene00001644
Caenorhabditis elegans	14538	WB:WBGene00001644
Xenopus tropicalis	51301	Xenbase:XB-GENE-1011770
Caenorhabditis elegans	64043	WB:WBGene00001644
Caenorhabditis elegans	72077	WB:WBGene00001644
Caenorhabditis elegans	140687	WB:WBGene00001644
Xenopus tropicalis	173109	Xenbase:XB-GENE-1011770

GlyTouCan

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UniCarb-DR

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Summary

External Links

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements