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ubiquitin conjugating enzyme E2 J1

Summary

Gene Symbol

UBE2J1

Organism

Homo sapiens (human)

External Links

NCBI Gene

51465

PubChem

51465

Alliance of Genome Resources

HGNC:17598

Annotation

Keyword

ATP-binding
Endoplasmic reticulum
Phosphoprotein
Proteomics identification
Reference proteome
Transferase
Transmembrane helix
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y385	E2 ubiquitin-conjugating enzyme J1 Non-canonical ubiquitin-conjugating enzyme 1 Yeast ubiquitin-conjugating enzyme UBC6 homolog E

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
protein polyubiquitination	IBA
spermatid development	IEA
regulation of macrophage cytokine production	IEA
protein N-linked glycosylation via asparagine	IMP	22607976
regulation of tumor necrosis factor production	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation [inference]

protein N-linked glycosylation via asparagine

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

spermatid development

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

spermatid development

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

spermatid development

cellular process involved in reproduction in multicellular organism [inference]

germ cell development [inference]

spermatid development

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development [inference]

spermatid development

anatomical structure development [inference]

cell development [inference]

germ cell development [inference]

spermatid development

cellular developmental process [inference]

cell development [inference]

germ cell development [inference]

spermatid development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune effector process [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of macrophage cytokine production

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of macrophage cytokine production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of macrophage cytokine production

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of macrophage cytokine production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of macrophage cytokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of macrophage cytokine production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of macrophage cytokine production

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of macrophage cytokine production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

regulation of cytokine production involved in immune response [inference]

regulation of macrophage cytokine production

negative regulation of cellular process [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

negative regulation of protein localization [inference]

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein exit from endoplasmic reticulum [inference]

negative regulation of retrograde protein transport, ER to cytosol

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

regulation of cytokine production involved in immune response [inference]

regulation of macrophage cytokine production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Hrd1p ubiquitin ligase complex	IDA	28827405
nucleus	IBA
endoplasmic reticulum membrane	IDA	33472082

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

endoplasmic reticulum protein-containing complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

intracellular protein-containing complex [inference]

ubiquitin ligase complex [inference]

cytoplasmic ubiquitin ligase complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex [inference]

cytoplasmic ubiquitin ligase complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

1

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GO Term	Evidence Code	PMID
protein binding	IDA	33472082
protein binding	IPI	19690564 22119785 28514442 28827405 32296183 32814053 33961781
ATP binding	IEA
ubiquitin protein ligase binding	IPI	11439185 24019521
ubiquitin conjugating enzyme activity	IMP	21245296