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platelet derived growth factor receptor alpha

Summary

Gene Symbol

PDGFRA

Organism

Homo sapiens (human)

External Links

NCBI Gene

5156

PubChem

5156

Alliance of Genome Resources

HGNC:8803

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Cell projection
Chemotaxis
Developmental protein
Disease variant
Disulfide bond
Glycoprotein
Golgi apparatus
Host-virus interaction
Immunoglobulin domain
Phosphoprotein
Proto-oncogene
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P16234	Alpha platelet-derived growth factor receptor Alpha-type platelet-derived growth factor receptor CD140 antigen-like family member A CD140a antigen Platelet-derived growth factor alpha receptor Platelet-derived growth factor receptor 2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
positive regulation of fibroblast proliferation	IDA	10806482
positive regulation of cell population proliferation	IDA IMP	10806482 2554309
metanephric glomerular capillary formation	ISS
cellular response to reactive oxygen species	IDA	24190966
wound healing	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

hormone metabolic process [inference]

estrogen metabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

estrogen metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation [inference]

peptidyl-amino acid modification [inference]

peptidyl-tyrosine modification [inference]

peptidyl-tyrosine phosphorylation

cellular process [inference]

cell activation

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

vascular endothelial growth factor signaling pathway [inference]

VEGF-activated platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

platelet-derived growth factor receptor signaling pathway

platelet-derived growth factor receptor-alpha signaling pathway

VEGF-activated platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

signal transduction involved in regulation of gene expression

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly [inference]

cardiac myofibril assembly

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation [inference]

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

white fat cell differentiation

cell motility [inference]

cell migration [inference]

cell chemotaxis

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

myofibril assembly [inference]

cardiac myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly [inference]

cardiac myofibril assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly [inference]

cardiac myofibril assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly [inference]

cardiac myofibril assembly

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

supramolecular fiber organization [inference]

myofibril assembly [inference]

cardiac myofibril assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

Leydig cell differentiation

reproductive structure development [inference]

genitalia development [inference]

male genitalia development

ovulation cycle process [inference]

luteinization

multicellular organismal process [inference]

cell activation

multicellular organism development

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

developmental process involved in reproduction [inference]

Leydig cell differentiation

reproductive structure development [inference]

genitalia development [inference]

male genitalia development

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

odontogenesis [inference]

odontogenesis of dentin-containing tooth

embryonic organ morphogenesis [inference]

embryonic digestive tract morphogenesis

embryonic skeletal system morphogenesis

embryonic cranial skeleton morphogenesis

skeletal system morphogenesis [inference]

embryonic skeletal system morphogenesis

embryonic cranial skeleton morphogenesis

embryonic morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic digestive tract morphogenesis

embryonic skeletal system morphogenesis

embryonic cranial skeleton morphogenesis

face morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

glomerular capillary formation [inference]

metanephric glomerular capillary formation

cellular component assembly involved in morphogenesis [inference]

myofibril assembly [inference]

cardiac myofibril assembly

anatomical structure development [inference]

multicellular organism development

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal organ development [inference]

lung development

gland development [inference]

adrenal gland development

genitalia development [inference]

male genitalia development

reproductive structure development [inference]

genitalia development [inference]

male genitalia development

system development [inference]

vasculature development [inference]

retina vasculature development in camera-type eye

reproductive system development [inference]

male genitalia development

roof of mouth development

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

white fat cell differentiation

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

rhythmic process [inference]

ovulation cycle process [inference]

luteinization

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to wounding [inference]

wound healing

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

response to amino acid [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to acid chemical [inference]

cellular response to amino acid stimulus

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus

cellular response to oxygen-containing compound [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of chemotaxis [inference]

positive regulation of chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of locomotion [inference]

positive regulation of chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell activation [inference]

negative regulation of platelet activation

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

regulation of chemotaxis [inference]

positive regulation of chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of stem cell differentiation [inference]

regulation of mesenchymal stem cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

vascular endothelial growth factor signaling pathway [inference]

VEGF-activated platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

platelet-derived growth factor receptor signaling pathway

platelet-derived growth factor receptor-alpha signaling pathway

VEGF-activated platelet-derived growth factor receptor signaling pathway [inference]

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

signal transduction involved in regulation of gene expression

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of calcium-mediated signaling [inference]

positive regulation of calcium-mediated signaling

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of fibroblast proliferation [inference]

positive regulation of fibroblast proliferation

regulation of cell differentiation [inference]

regulation of stem cell differentiation [inference]

regulation of mesenchymal stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of ERK1 and ERK2 cascade

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell activation [inference]

negative regulation of platelet activation

regulation of cell activation [inference]

regulation of platelet activation [inference]

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

regulation of cell activation [inference]

regulation of platelet activation [inference]

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

negative regulation of multicellular organismal process [inference]

negative regulation of coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of cell activation [inference]

negative regulation of platelet activation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

estrogen metabolic process

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

negative regulation of hemostasis [inference]

negative regulation of blood coagulation [inference]

negative regulation of platelet activation

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GO Term	Evidence Code	PMID
external side of plasma membrane	IEA
cell junction	IDA
membrane	HDA	19946888
Golgi apparatus	ISS
microvillus	IEA

GO Hierarchy

cellular component

protein-containing complex

receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

cell junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

cilium

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
platelet-derived growth factor alpha-receptor activity	IBA IDA IMP	10806482 2536956 2554309 8188664
protein binding	IPI	10733900 10806482 11297552 17470632 18701889 20534510 24658140 25241761 25416956 31980649 32296183 32814053 35384245 36931259 7679113 9546424
vascular endothelial growth factor receptor activity	IDA	17470632
protein-containing complex binding	IEA
platelet-derived growth factor binding	IBA IDA IPI	10806482 2536956 2554309 8188664

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

vascular endothelial growth factor receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

vascular endothelial growth factor receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein tyrosine kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

vascular endothelial growth factor receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

vascular endothelial growth factor receptor activity

binding [inference]

protein binding

signaling receptor binding [inference]

growth factor receptor binding [inference]

platelet-derived growth factor receptor binding

growth factor binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein tyrosine kinase activity

platelet-derived growth factor receptor activity [inference]

platelet-derived growth factor alpha-receptor activity

vascular endothelial growth factor receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

platelet-derived growth factor receptor beta

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 10** entries
Gene Ontology
ATP binding
angiogenesis
cell chemotaxis
metal ion binding
nucleotide binding
platelet-derived growth factor beta-receptor activity
platelet-derived growth factor binding
positive regulation of smooth muscle cell migration
transmembrane receptor protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase signaling pathway

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InterPro
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050902	medulloblastoma	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:12215	oligohydramnios	Alliance of Genome Resources
DOID:1240	leukemia	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2526	prostate adenocarcinoma	Alliance of Genome Resources
DOID:2696	Leydig cell tumor	Alliance of Genome Resources
DOID:3459	breast carcinoma	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18595	MGI:97530	MOUSE44102
Rattus norvegicus	25267	RGD:3284	RATNO08104
Drosophila melanogaster	33543	FB:FBgn0031518
Drosophila melanogaster	35717	FB:FBgn0003733
Drosophila melanogaster	38559	FB:FBgn0014073
Caenorhabditis elegans	174501	WB:WBGene00011168
Caenorhabditis elegans	175182	WB:WBGene00006894
Caenorhabditis elegans	180032	WB:WBGene00002211
Bos taurus	282301		BOVIN31497
Xenopus laevis	380245	Xenbase:XB-GENE-6072934

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements