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pyruvate dehydrogenase E1 subunit beta
Summary
- Gene Symbol
-
- PDHB
- Aliases
-
- E1beta
- PDHE1B
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Glucose metabolism
- Mitochondrion
- Oxidoreductase
- Phosphoprotein
- Pyruvate
- Reference proteome
- Thiamine pyrophosphate
- Transit peptide
- Tricarboxylic acid cycle
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A384MDR8 |
|
| P11177 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| glucose metabolic process | ||
| acetyl-CoA biosynthetic process from pyruvate | ||
| acetyl-CoA biosynthetic process from pyruvate | ||
| acetyl-CoA biosynthetic process from pyruvate | ||
| acetyl-CoA biosynthetic process from pyruvate |
GO Hierarchy
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
organonitrogen compound metabolic process [inference]
biosynthetic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
organophosphate metabolic process [inference]
organic cyclic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
purine-containing compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
organic substance biosynthetic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
aromatic compound biosynthetic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
organophosphate metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
cellular nitrogen compound biosynthetic process [inference]
cellular biosynthetic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
heterocycle biosynthetic process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| nucleoplasm | ||
| mitochondrion | ||
| mitochondrion | ||
| mitochondrion |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| pyruvate dehydrogenase (acetyl-transferring) activity | ||
| protein binding | ||
| pyruvate dehydrogenase (NAD+) activity | ||
| metal ion binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- pyruvate dehydrogenase E1 component, beta subunit
- Functional Category
-
- C: Energy production and conversion
- G: Carbohydrate transport and metabolism
- H: Coenzyme transport and metabolism
- I: Lipid transport and metabolism
| Gene Ontology |
|---|
| acetyl-CoA biosynthetic process from pyruvate |
| catalytic activity |
| oxidoreductase activity |
| pyruvate dehydrogenase (acetyl-transferring) activity |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:3649 | pyruvate decarboxylase deficiency |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0001250 | Seizure |
| HP:0001251 | Ataxia |
| HP:0001252 | Hypotonia |
| HP:0001263 | Global developmental delay |
| HP:0001265 | Hyporeflexia |
| HP:0001274 | Agenesis of corpus callosum |
| HP:0001290 | Generalized hypotonia |
| HP:0001302 | Pachygyria |
| HP:0001315 | Reduced tendon reflexes |
| Disease ID | Disease Name |
|---|---|
| ORPHA:255138 |
|
| OMIM:614111 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP005062
- Gene Name
- pyruvate dehydrogenase (lipoamide) beta
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 5162 | Xenbase:XB-GENE-977343 | ||
| 68263 | Xenbase:XB-GENE-977343 | MOUSE14843 | |
| 289950 | Xenbase:XB-GENE-977343 | RATNO09943 | |
| 406428 | DANRE22850 | ||
| 470832 | PANTR31439 | ||
| 476574 | CANLF07388 | ||
| 574227 | MACMU29844 | ||
| 613610 | BOVIN17595 | ||
| 100014556 | MONDO29826 | ||
| 100049362 | ORYLA20156 |
