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pyruvate dehydrogenase kinase 2

Summary

Gene Symbol

PDK2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5164

PubChem

5164

Alliance of Genome Resources

HGNC:8810

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Kinase
Mitochondrion
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15119	Pyruvate dehydrogenase kinase isoform 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
regulation of glucose metabolic process	IBA ISS
insulin receptor signaling pathway	ISS
glucose metabolic process	TAS	7499431
regulation of acetyl-CoA biosynthetic process from pyruvate	IBA ISS
regulation of calcium-mediated signaling	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

regulation of pH

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

biological regulation [inference]

regulation of pH

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of sulfur metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of amide metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular ketone metabolic process

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of glucose metabolic process

regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process

regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of sulfur metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrial matrix	TAS
nucleoplasm	IDA
cytosol	IDA
pyruvate dehydrogenase complex	ISS
mitochondrion	HTP IBA IDA	34800366

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

oxidoreductase complex [inference]

pyruvate dehydrogenase complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ATP binding	IDA	16401071
protein binding	IPI	16169070 32814053
protein kinase activity	TAS	10748134 7499431
pyruvate dehydrogenase (acetyl-transferring) kinase activity	IBA IDA	19833728
protein homodimerization activity	IPI	19833728