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endoplasmic reticulum aminopeptidase 1

Summary

Gene Symbol

ERAP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

51752

PubChem

51752

Alliance of Genome Resources

HGNC:18173

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Aminopeptidase
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NZ08	ARTS-1 Adipocyte-derived leucine aminopeptidase Aminopeptidase PILS Puromycin-insensitive leucyl-specific aminopeptidase Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
angiogenesis	TAS	15691326
adaptive immune response	IEA
antigen processing and presentation of peptide antigen via MHC class I	TAS
proteolysis	IBA
membrane protein ectodomain proteolysis	IDA	12748171

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

antigen processing and presentation [inference]

antigen processing and presentation of endogenous antigen [inference]

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organonitrogen compound catabolic process [inference]

peptide catabolic process

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

organonitrogen compound catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

peptide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

immune response [inference]

adaptive immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response [inference]

regulation of innate immune response

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response

regulation of response to external stimulus [inference]

regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

regulation of blood pressure

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GO Term	Evidence Code	PMID
extracellular region	IDA	11056387
extracellular space	IBA
extracellular space	HDA	16502470
cytoplasm	IBA
endoplasmic reticulum	NAS	12748171

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	EXP	12436109 12436110 17088086
aminopeptidase activity	IDA	10220586 12748171
interleukin-6 receptor binding	IPI	12748171
interleukin-1, type II receptor binding	TAS	15691326
protein binding	IPI	15908954 18445477

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity

metalloaminopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity

metalloaminopeptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

interleukin-6 receptor binding

interleukin-1 receptor binding [inference]

interleukin-1, type II receptor binding

growth factor receptor binding [inference]

interleukin-6 receptor binding

interleukin-1 receptor binding [inference]

interleukin-1, type II receptor binding

amide binding [inference]

peptide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

aminopeptidase

Functional Category

E: Amino acid transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 9** entries
Gene Ontology
aminopeptidase activity
hydrolase activity
metal ion binding
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
peptide catabolic process
proteolysis
zinc ion binding

Displaying **all 7** entries
InterPro
Aminopeptidase N-like , N-terminal domain superfamliy
Aminopeptidase N-like , N-terminal domain
Aminopeptidase N-type
ERAP1-like C-terminal domain
Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
Peptidase M1, membrane alanine aminopeptidase
Peptidase M4/M1, CTD superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2893	cervix carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 96 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	290	SGD:S000001399
Saccharomyces cerevisiae S288C	2028	SGD:S000001399
Saccharomyces cerevisiae S288C	4012	SGD:S000001399
Saccharomyces cerevisiae S288C	13809	SGD:S000001399
Saccharomyces cerevisiae S288C	16790	SGD:S000001399
Saccharomyces cerevisiae S288C	29953	SGD:S000001399
Xenopus tropicalis	51752	Xenbase:XB-GENE-983344
Saccharomyces cerevisiae S288C	64017	SGD:S000001399
Saccharomyces cerevisiae S288C	64167	SGD:S000001399
Rattus norvegicus	80897		RATNO24332