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RAB8B, member RAS oncogene family

Summary

Gene Symbol

RAB8B

Organism

Homo sapiens (human)

External Links

NCBI Gene

51762

PubChem

51762

Alliance of Genome Resources

HGNC:30273

Annotation

Keyword

Cell membrane
Cytoplasmic vesicle
Endosome
GTP-binding
Hydrolase
Magnesium
Metal-binding
Methylation
Phosphoprotein
Prenylation
Protein transport
Proteomics identification
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92930

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
exocytosis	IBA
protein secretion
antigen processing and presentation	IMP	19717423
positive regulation of cell projection organization	IEA
endocytic recycling	IBA

GO Hierarchy

biological process

immune system process [inference]

antigen processing and presentation

cellular process [inference]

vesicle-mediated transport [inference]

exocytosis

endosomal transport [inference]

endocytic recycling

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

endosomal transport [inference]

endocytic recycling

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

peroxisome organization [inference]

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

cell junction organization [inference]

cell-substrate junction organization

export from cell [inference]

secretion by cell [inference]

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis

endosomal transport [inference]

endocytic recycling

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

secretion [inference]

secretion by cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

endosomal transport [inference]

endocytic recycling

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

protein secretion

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

protein secretion

export from cell [inference]

secretion by cell [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

endosomal transport [inference]

endocytic recycling

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

endosomal transport [inference]

endocytic recycling

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of peptide hormone secretion [inference]

regulation of corticotropin secretion [inference]

positive regulation of corticotropin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of peptide hormone secretion [inference]

regulation of corticotropin secretion [inference]

positive regulation of corticotropin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of peptide hormone secretion [inference]

regulation of corticotropin secretion [inference]

positive regulation of corticotropin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of peptide hormone secretion [inference]

regulation of corticotropin secretion [inference]

positive regulation of corticotropin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of multicellular organismal process [inference]

positive regulation of corticotropin secretion

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of peptide hormone secretion [inference]

regulation of corticotropin secretion [inference]

positive regulation of corticotropin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of peptide hormone secretion [inference]

regulation of corticotropin secretion [inference]

positive regulation of corticotropin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of endocrine process [inference]

regulation of corticotropin secretion [inference]

positive regulation of corticotropin secretion

positive regulation of multicellular organismal process [inference]

positive regulation of corticotropin secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

regulation of peptide hormone secretion [inference]

regulation of corticotropin secretion [inference]

positive regulation of corticotropin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of corticotropin secretion

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
endosome	IBA
peroxisomal membrane	IDA	18346465
plasma membrane	IBA
synaptic vesicle	IBA
endosome membrane	IDA	32344433

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

recycling endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

bounding membrane of organelle [inference]

endosome membrane

recycling endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

microbody membrane [inference]

peroxisomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

microbody [inference]

microbody membrane [inference]

peroxisomal membrane

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

microbody membrane [inference]

peroxisomal membrane

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

cell pole [inference]

cell tip

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
GTPase activity	NAS	9030196
GTPase activity	IBA
signaling receptor binding	IPI	18346465
protein binding	IPI	17646400 32344433
GTP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding

signaling receptor binding

protein domain specific binding [inference]

TPR domain binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

GDP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

RAB

Functional Category

T: Signal transduction mechanisms
U: Intracellular trafficking, secretion, and vesicular transport

Displaying 1 entry
Gene Ontology
GTP binding

Displaying **all 3** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Small GTP-binding protein domain
Small GTPase

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	51762	Xenbase:XB-GENE-480278
Mus musculus	235442	Xenbase:XB-GENE-480278	MOUSE63750
Rattus norvegicus	266688		RATNO40442
Pan troglodytes	453498		PANTR10501
Bos taurus	614242		BOVIN01214
Monodelphis domestica	100016883		MONDO05059
Equus caballus	100054073		HORSE15457
Danio rerio	100093706		DANRE41489
Sus scrofa	100153972		PIGXX14160
Taeniopygia guttata	100230238		TAEGU02092

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Acknowledgements