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complement factor properdin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

5199

PubChem

5199

Alliance of Genome Resources

HGNC:8864

Annotation

Keyword

3D-structure
Complement alternate pathway
Disease variant
Disulfide bond
Glycoprotein
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P27918	Complement factor P
A0A0S2Z4I5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
positive regulation of immune response	NAS	23901101
complement activation, alternative pathway	IEA
immune response	TAS	8530058
positive regulation of opsonization	NAS	23901101
defense response to bacterium	TAS	8530058

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, alternative pathway

activation of immune response [inference]

complement activation

complement activation, alternative pathway

immune response

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

complement activation, alternative pathway

immune response

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of opsonization

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of opsonization

regulation of opsonization [inference]

positive regulation of opsonization

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of opsonization

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of opsonization [inference]

positive regulation of opsonization

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
secretory granule
specific granule lumen	TAS
collagen-containing extracellular matrix	HDA	20551380
tertiary granule lumen	TAS
endoplasmic reticulum lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

tertiary granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of Golgi membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	22518841 24355864 26984957 28086806 28480349 28533443 32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

thrombospondin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111768	X-linked properdin deficiency	Alliance of Genome Resources
DOID:12134	factor VIII deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18636		MGI:97545	MOUSE66669
Rattus norvegicus	299314		RGD:1594557	RATNO44975
Pan troglodytes	465607	9598_0:0056ac		PANTR45894
Canis lupus familiaris	491859			CANLF19734
Xenopus tropicalis	496476		Xenbase:XB-GENE-5941221
Danio rerio	556399		ZFIN:ZDB-GENE-030131-9247	DANRE42873
Macaca mulatta	707386			MACMU47709
Monodelphis domestica	100017759			MONDO36529
Equus caballus	100051317			HORSE44851
Ornithorhynchus anatinus	100080161			ORNAN23221