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complement factor properdin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

5199

PubChem

5199

Alliance of Genome Resources

HGNC:8864

Annotation

Keyword

3D-structure
Complement alternate pathway
Disease variant
Disulfide bond
Glycoprotein
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P27918	Complement factor P
A0A0S2Z4I5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
positive regulation of immune response	NAS	23901101
complement activation, alternative pathway	IEA
immune response	TAS	8530058
positive regulation of opsonization	NAS	23901101
defense response to bacterium	TAS	8530058

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, alternative pathway

activation of immune response [inference]

complement activation

complement activation, alternative pathway

immune response

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

complement activation, alternative pathway

immune response

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of opsonization

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of opsonization

regulation of opsonization [inference]

positive regulation of opsonization

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of opsonization

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of opsonization

regulation of opsonization [inference]

positive regulation of opsonization

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IEA
cytoplasmic side of Golgi membrane	IDA NAS	23901101

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

specific granule lumen

tertiary granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of Golgi membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	22518841 24355864 26984957 28086806 28480349 28533443 32296183

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

thrombospondin

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111768	X-linked properdin deficiency	Alliance of Genome Resources
DOID:12134	factor VIII deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 70 in total

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Species	Gene ID	Orthologous MAtrix
Jaculus jaculus	101607490	JACJA20637
Mustela putorius furo	101688284	MUSPF12420
Ictidomys tridecemlineatus	101961626	ICTTR14634
Macaca fascicularis	102145785	MACFA44183
Capra hircus	102169844	CAPHI30749
Myotis lucifugus	102420158	MYOLU10355
Lepisosteus oculatus	102685295	LEPOC00016
Astyanax mexicanus	103043236	ASTMX01776
Chlorocebus sabaeus	103231897	CHLSB18414
Carlito syrichta	103270868	CARSF24680