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phosphofructokinase, muscle
Summary
- Gene Symbol
-
- PFKM
- Aliases
-
- PFK-1
- PPP1R122
- protein phosphatase 1, regulatory subunit 122
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Allosteric enzyme
- Alternative splicing
- Cytoplasm
- Disease variant
- Glycogen storage disease
- Glycolysis
- Glycoprotein
- Hydroxylation
- Kinase
- Magnesium
- Metal-binding
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A2R8Y891 |
|
| A0A024R0Y5 |
|
| P08237 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| muscle cell cellular homeostasis | ||
| positive regulation of transcription by RNA polymerase II | ||
| glycolysis from storage polysaccharide through glucose-1-phosphate | ||
| glycogen catabolic process | ||
| fructose 6-phosphate metabolic process |
GO Hierarchy
- fructose 6-phosphate metabolic process
- fructose 1,6-bisphosphate metabolic process
- fructose 6-phosphate metabolic process
- fructose 1,6-bisphosphate metabolic process
- fructose 6-phosphate metabolic process
- fructose 1,6-bisphosphate metabolic process
- fructose 6-phosphate metabolic process
- fructose 1,6-bisphosphate metabolic process
- fructose 6-phosphate metabolic process
- fructose 1,6-bisphosphate metabolic process
biological process
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound catabolic process [inference]
nucleobase-containing small molecule metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
cellular nitrogen compound catabolic process [inference]
purine-containing compound metabolic process [inference]
organonitrogen compound metabolic process [inference]
catabolic process [inference]
cellular catabolic process [inference]
aromatic compound catabolic process [inference]
cellular nitrogen compound catabolic process [inference]
heterocycle catabolic process [inference]
organic substance catabolic process [inference]
organophosphate catabolic process [inference]
organic cyclic compound catabolic process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound catabolic process [inference]
nucleobase-containing small molecule metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
aromatic compound catabolic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
ribose phosphate metabolic process [inference]
organophosphate metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
ribose phosphate metabolic process [inference]
organophosphate catabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound catabolic process [inference]
nucleobase-containing small molecule metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
cellular nitrogen compound catabolic process [inference]
purine-containing compound metabolic process [inference]
cellular catabolic process [inference]
aromatic compound catabolic process [inference]
cellular nitrogen compound catabolic process [inference]
heterocycle catabolic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound catabolic process [inference]
nucleobase-containing small molecule metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
heterocycle catabolic process [inference]
purine-containing compound metabolic process [inference]
primary metabolic process [inference]
carbohydrate metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound catabolic process [inference]
nucleobase-containing small molecule metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
small molecule metabolic process [inference]
nucleobase-containing small molecule metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
organic substance metabolic process [inference]
carbohydrate metabolic process [inference]
organophosphate metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
ribose phosphate metabolic process [inference]
organophosphate catabolic process [inference]
carbohydrate derivative metabolic process [inference]
organic cyclic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound catabolic process [inference]
nucleobase-containing small molecule metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
purine-containing compound metabolic process [inference]
pyridine-containing compound metabolic process [inference]
organic cyclic compound catabolic process [inference]
organonitrogen compound metabolic process [inference]
organic substance catabolic process [inference]
organophosphate catabolic process [inference]
organic cyclic compound catabolic process [inference]
cellular process [inference]
cellular metabolic process [inference]
cellular aromatic compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound catabolic process [inference]
nucleobase-containing small molecule metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
aromatic compound catabolic process [inference]
phosphorus metabolic process [inference]
phosphate-containing compound metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
ribose phosphate metabolic process [inference]
organophosphate metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
ribose phosphate metabolic process [inference]
organophosphate catabolic process [inference]
cellular nitrogen compound metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound catabolic process [inference]
nucleobase-containing small molecule metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
cellular nitrogen compound catabolic process [inference]
purine-containing compound metabolic process [inference]
cellular catabolic process [inference]
aromatic compound catabolic process [inference]
cellular nitrogen compound catabolic process [inference]
heterocycle catabolic process [inference]
heterocycle metabolic process [inference]
nucleobase-containing compound metabolic process [inference]
nucleobase-containing compound catabolic process [inference]
nucleobase-containing small molecule metabolic process [inference]
nucleoside phosphate metabolic process [inference]
nucleotide metabolic process [inference]
nucleoside diphosphate metabolic process [inference]
nucleoside triphosphate metabolic process [inference]
nucleoside phosphate catabolic process [inference]
heterocycle catabolic process [inference]
purine-containing compound metabolic process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| fructose-6-phosphate binding | ||
| 6-phosphofructokinase activity | ||
| kinase binding | ||
| AMP binding | ||
| monosaccharide binding |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0090031 | D-bifunctional protein deficiency | |
| DOID:0090129 | carnitine palmitoyltransferase I deficiency | |
| DOID:0111040 | glycogen storage disease IXd | |
| DOID:0111041 | glycogen storage disease IXb | |
| DOID:0111042 | glycogen storage disease IXa | |
| DOID:0111043 | glycogen storage disease IXc | |
| DOID:10211 | cholelithiasis | |
| DOID:11151 | cholecystolithiasis | |
| DOID:11721 | glycogen storage disease VII |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000790 | Hematuria |
| HP:0000952 | Jaundice |
| HP:0001081 | Cholelithiasis |
| HP:0001324 | Muscle weakness |
| HP:0001878 | Hemolytic anemia |
| HP:0001903 | Anemia |
| HP:0001923 | Reticulocytosis |
| HP:0001997 | Gout |
| HP:0002149 | Hyperuricemia |
| Disease ID | Disease Name |
|---|---|
| OMIM:232800 |
|
| ORPHA:371 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100754270 | CRIGR23651 | ||
| 18642 | MGI:97548 | MOUSE16182 | |
| 65152 | RGD:68419 | RATNO38492 | |
| 100733625 | CAVPO05714 | ||
| 101563155 | OCTDE16690 | ||
| 102448872 | PELSI05050 | ||
| 100552812 | ANOCA12836 | ||
| 114029778 | VOMUR22346 | ||
| 113893058 | BOBOX40567 | ||
| 105867117 | MICMU13347 |
