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placental growth factor

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

5228

PubChem

5228

Alliance of Genome Resources

HGNC:8893

Annotation

Keyword

3D-structure
Alternative splicing
Angiogenesis
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor
Heparin-binding
Mitogen
Proteomics identification
Reference proteome
Secreted
Signal

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P49763
G3XA84
Q53XY6
Q86TW6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IBA
positive regulation of endothelial cell proliferation
sprouting angiogenesis	IBA
signal transduction	TAS	9467961
cell-cell signaling	TAS	9467961

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis [inference]

sprouting angiogenesis

cellular developmental process [inference]

cell differentiation

locomotion [inference]

taxis [inference]

chemotaxis [inference]

positive chemotaxis

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of mast cell chemotaxis [inference]

positive regulation of mast cell chemotaxis

signaling [inference]

cell-cell signaling

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of mast cell chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of positive chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of mast cell chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cell division

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of mast cell chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of positive chemotaxis [inference]

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of positive chemotaxis [inference]

induction of positive chemotaxis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of cell division

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of cell division [inference]

positive regulation of cell division

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of mast cell chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of mast cell chemotaxis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IBA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
vascular endothelial growth factor receptor binding	IBA
protein binding	IPI	14684734 20660291
growth factor activity	IMP	21215706
growth factor activity	IBA
heparin binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

vascular endothelial growth factor receptor binding

receptor ligand activity [inference]

growth factor receptor binding [inference]

vascular endothelial growth factor receptor binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Vascular endothelial growth factor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
chemoattractant activity
growth factor activity
induction of positive chemotaxis
positive regulation of angiogenesis
positive regulation of endothelial cell proliferation
positive regulation of mast cell chemotaxis
positive regulation of protein phosphorylation
response to hypoxia
sprouting angiogenesis
vascular endothelial growth factor receptor signaling pathway

Displaying **all 3** entries
InterPro
Cystine-knot cytokine
PDGF/VEGF domain
Platelet-derived growth factor, conserved site

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:1798	pancreatic endocrine carcinoma	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:3068	glioblastoma	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:9743	diabetic neuropathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 40 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5228	Xenbase:XB-GENE-483494
Mus musculus	18654	ZFIN:ZDB-GENE-131127-445	MOUSE07780
Rattus norvegicus	94203	ZFIN:ZDB-GENE-120928-4	RATNO35728
Bos taurus	280894		BOVIN01741
Macaca mulatta	701219		MACMU42950
Pan troglodytes	741830		PANTR09176
Monodelphis domestica	100023623		MONDO03372
Taeniopygia guttata	100221017		TAEGU24836
Oryctolagus cuniculus	100339515		RABIT09012
Callithrix jacchus	100386568		CALJA02085

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements