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phosphoglucomutase 3

Summary

Gene Symbol

PGM3

Aliases

AGM1
DKFZP434B187
PAGM
acetylglucosamine phosphomutase
phosphoacetylglucosamine mutase

Organism

Homo sapiens (human)

External Links

NCBI Gene

5238

HGNC

8907

KEGG Gene ID

hsa:5238

PubChem

5238

Alliance of Genome Resources

HGNC:8907

Annotation

Keyword

Acetylation
Alternative splicing
Carbohydrate metabolism
Coiled coil
Disease variant
Isomerase
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O95394	Acetylglucosamine phosphomutase N-acetylglucosamine-phosphate mutase Phosphoglucomutase-3
J3KN95	Acetylglucosamine phosphomutase N-acetylglucosamine-phosphate mutase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein N-linked glycosylation	IMP	24589341
protein O-linked glycosylation	IMP	24589341
carbohydrate metabolic process	IEA
spermatogenesis	IEA
UDP-N-acetylglucosamine biosynthetic process	IBA IEA IMP TAS	24589341

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

amino sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

phosphorus metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

amino sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

glucosamine-containing compound metabolic process [inference]

glucosamine metabolic process

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

amino sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

organic substance biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

amino sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

phosphorus metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylglucosamine metabolic process [inference]

UDP-N-acetylglucosamine biosynthetic process

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-N-acetylglucosamine biosynthetic process

cellular developmental process [inference]

cell development [inference]

hemopoiesis

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure development [inference]

cell development [inference]

hemopoiesis

cellular developmental process [inference]

cell development [inference]

hemopoiesis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	TAS
cellular_component	ND

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phosphoacetylglucosamine mutase activity	IBA IDA IMP TAS	11004509 24589341
magnesium ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

intramolecular transferase activity [inference]

intramolecular phosphotransferase activity [inference]

phosphoacetylglucosamine mutase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000013375

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01836

Name

phosphoacetylglucosamine mutase [EC:5.4.2.3]

References

11004509

Rhea

RHEA:23804

N-acetyl-α-D-glucosamine 1-phosphate

N-acetyl-D-glucosamine 6-phosphate

Enzyme

5.4.2.3

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 62 in total

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DO ID	Disease Name	Source
DOID:0040085	bacterial sepsis	DisGeNET
DOID:0050590	severe congenital neutropenia	DisGeNET
DOID:0060058	lymphoma	DisGeNET
DOID:0060249	scoliosis	DisGeNET
DOID:0060462	Desbuquois dysplasia	DisGeNET
DOID:0111953	immunodeficiency 23	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	DisGeNET
DOID:1019	osteomyelitis	DisGeNET
DOID:1040	chronic lymphocytic leukemia	DisGeNET DisGeNET
DOID:1059	intellectual disability	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000218	High palate
HP:0000389	Chronic otitis media
HP:0000405	Conductive hearing impairment
HP:0000407	Sensorineural hearing impairment
HP:0000793	Membranoproliferative glomerulonephritis
HP:0000924	Abnormality of the skeletal system
HP:0000964	Eczematoid dermatitis
HP:0001047	Atopic dermatitis
HP:0001156	Brachydactyly

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:615816	immunodeficiency 23
ORPHA:443811	immunodeficiency 23

PubChem Disease

GHR Health Conditions

PGM3-congenital disorder of glycosylation

MedGen Diseases

Immunodeficiency 23

OMIM Phenotypes

IMMUNODEFICIENCY 23; IMD23

KEGG Diseases

Hyper-IgE syndrome

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	177678	WB:WBGene00009006
Drosophila melanogaster	39434	FB:FBgn0036298
Ciona intestinalis	100184742		CIOIN12923
Callorhinchus milii	103178892		CALMI16557
Danio rerio	474321	ZFIN:ZDB-GENE-041024-13	DANRE34356
Astyanax mexicanus	125799118		ASTMX10283
Ictalurus punctatus	108279698		ICTPU12372
Electrophorus electricus	113578118		ELEEL21275
Salmo salar	100194862		SALSA36425
Salmo trutta	115191559		SALTR24054

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements