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ATP binding cassette subfamily B member 1

Summary

Gene Symbol

ABCB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5243

PubChem

5243

Alliance of Genome Resources

HGNC:40

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Cytoplasm
Glycoprotein
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P08183	ATP-binding cassette sub-family B member 1 Multidrug resistance protein 1 P-glycoprotein 1 Phospholipid transporter ABCB1
A4D1D2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 17 in total

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GO Term	Evidence Code	PMID
transepithelial transport	IDA IMP	25986174 28757552
terpenoid transport	ISS
carboxylic acid transmembrane transport	IMP	25986174
transmembrane transport	TAS
export across plasma membrane	IDA IMP	25986174 28587984

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

xenobiotic metabolic process

cellular process [inference]

cell population proliferation [inference]

stem cell proliferation

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cell cycle G2/M phase transition [inference]

G2/M transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cellular metabolic process [inference]

xenobiotic metabolic process

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport across blood-brain barrier

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport across blood-brain barrier

xenobiotic transport [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

xenobiotic transport across blood-brain barrier

transmembrane transport

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

transepithelial transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport [inference]

phospholipid translocation

lipid translocation [inference]

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

ceramide transport [inference]

ceramide translocation

isoprenoid transport [inference]

terpenoid transport

organic anion transport [inference]

carboxylic acid transport [inference]

carboxylic acid transmembrane transport

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid translocation

organic acid transport [inference]

carboxylic acid transport [inference]

carboxylic acid transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport

nitrogen compound transport [inference]

amide transport [inference]

ceramide transport [inference]

ceramide translocation

sphingolipid translocation [inference]

ceramide translocation

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane

xenobiotic detoxification by transmembrane export across the plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transport [inference]

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of chloride transport

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of monoatomic anion transport [inference]

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of response to osmotic stress

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of monoatomic anion transmembrane transport [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of anion transmembrane transport [inference]

positive regulation of anion channel activity

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of anion channel activity [inference]

positive regulation of anion channel activity

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

positive regulation of molecular function [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of anion channel activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
membrane	IDA	26006083
apical plasma membrane	IBA IDA	16361082 28408210 31791063 8898203
plasma membrane	IDA TAS	18619525 23137377 35970996
cell surface	IDA	19384922
external side of apical plasma membrane	ISS	18619525

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane [inference]

external side of apical plasma membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
phosphatidylethanolamine flippase activity	IDA	8898203
protein binding	IPI	17088979 20711237
phosphatidylcholine floppase activity	IBA IDA	8898203
ceramide floppase activity	IDA	8898203
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

phosphatidylcholine transporter activity [inference]

phosphatidylcholine floppase activity

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

sphingolipid transporter activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

transmembrane transporter activity

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity

efflux transmembrane transporter activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

xenobiotic transmembrane transporter activity

ABC-type xenobiotic transporter activity

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity [inference]

ABC-type xenobiotic transporter activity

ATPase-coupled intramembrane lipid transporter activity [inference]

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylethanolamine flippase activity

floppase activity

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying entries **31 - 40** of 45 in total

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DO ID	Disease Name	Source
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:4450	renal cell carcinoma	Alliance of Genome Resources
DOID:4481	allergic rhinitis	Alliance of Genome Resources
DOID:526	human immunodeficiency virus infectious disease	Alliance of Genome Resources
DOID:635	acquired immunodeficiency syndrome	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:8552	chronic myeloid leukemia	Alliance of Genome Resources
DOID:8577	ulcerative colitis	Alliance of Genome Resources
DOID:8778	Crohn's disease	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of **111** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	180165		WB:WBGene00004003
Caenorhabditis elegans	181326		WB:WBGene00003997
Bos taurus	281585			BOVIN27811
Sus scrofa	396910			PIGXX36286
Canis lupus familiaris	403879			CANLF03622
Pan troglodytes	463516	9598_0:002022		PANTR40676
Felis catus	493707			FELCA03604
Macaca mulatta	574235			MACMU31987
Macaca mulatta	706683			MACMU31987
Saccharomyces cerevisiae S288C	853671		SGD:S000001692

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OrthoDB (Group)

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Acknowledgements