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ATP binding cassette subfamily B member 4

Summary

Gene Symbol

ABCB4

Organism

Homo sapiens (human)

External Links

NCBI Gene

5244

PubChem

5244

Alliance of Genome Resources

HGNC:45

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Disease variant
Glycoprotein
Intrahepatic cholestasis
Lipid transport
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P21439	ATP-binding cassette sub-family B member 4 Multidrug resistance protein 3 P-glycoprotein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
positive regulation of phospholipid translocation	IDA	17523162
ceramide translocation	IDA	8898203
bile acid secretion	ISS
response to fenofibrate	ISS
phospholipid translocation	IBA IDA IMP	24806754 8898203

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

cellular response to organic cyclic compound [inference]

cellular response to bile acid

response to fenofibrate

response to bile acid [inference]

cellular response to bile acid

response to lipid [inference]

cellular response to lipid [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

response to ether [inference]

response to fenofibrate

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

response to ketone [inference]

response to fenofibrate

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to oxygen-containing compound [inference]

response to ether [inference]

response to fenofibrate

response to ketone [inference]

response to fenofibrate

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

response to bile acid [inference]

cellular response to bile acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to bile acid

cellular response to organic cyclic compound [inference]

cellular response to bile acid

cellular response to oxygen-containing compound [inference]

cellular response to bile acid

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

acid secretion [inference]

bile acid secretion

transmembrane transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport [inference]

phospholipid translocation

lipid translocation [inference]

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

ceramide transport [inference]

ceramide translocation

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid secretion

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid translocation

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid secretion

nitrogen compound transport [inference]

amide transport [inference]

ceramide transport [inference]

ceramide translocation

sphingolipid translocation [inference]

ceramide translocation

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport

regulation of phospholipid transport [inference]

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport

positive regulation of phospholipid transport

positive regulation of phospholipid translocation

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of phospholipid translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

sphingolipid translocation [inference]

ceramide translocation

regulation of phospholipid translocation [inference]

positive regulation of phospholipid translocation

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GO Term	Evidence Code	PMID
membrane	TAS	7912658
intercellular canaliculus	IEA
focal adhesion	IDA
apical plasma membrane	IBA IDA	15258199 19674157 24122873 8898203
clathrin-coated vesicle	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

intercellular canaliculus

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
protein binding	IPI	19674157
ABC-type transporter activity	IEA
phosphatidylcholine floppase activity	IBA IDA IMP	17523162 24045840 24806754 31873305 8898203
ceramide floppase activity	IDA	8898203
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity

phosphatidylcholine transporter activity [inference]

phosphatidylcholine floppase activity

sphingolipid transporter activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity [inference]

floppase activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

ATPase-coupled intramembrane lipid transporter activity [inference]

floppase activity [inference]

sphingolipid floppase activity [inference]

ceramide floppase activity

phosphatidylcholine floppase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0060643	primary sclerosing cholangitis	Alliance of Genome Resources
DOID:0070223	progressive familial intrahepatic cholestasis 3	Alliance of Genome Resources
DOID:0070229	intrahepatic cholestasis of pregnancy 3	Alliance of Genome Resources
DOID:12236	primary biliary cholangitis	Alliance of Genome Resources
DOID:13580	cholestasis	Alliance of Genome Resources
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:1852	intrahepatic cholestasis	Alliance of Genome Resources
DOID:1949	cholecystitis	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18670	MGI:97569	MOUSE44040
Rattus norvegicus	24891	RGD:620248	RATNO30604
Drosophila melanogaster	36428	FB:FBgn0004512
Drosophila melanogaster	36582	FB:FBgn0010241
Drosophila melanogaster	38725	FB:FBgn0035695
Drosophila melanogaster	38726	FB:FBgn0004513
Caenorhabditis elegans	172262	WB:WBGene00003996
Caenorhabditis elegans	178215	WB:WBGene00003995
Caenorhabditis elegans	180165	WB:WBGene00004003
Caenorhabditis elegans	181326	WB:WBGene00003997

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OrthoDB (Group)

International Collaboration

Acknowledgements