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PHD finger protein 1

Summary

Gene Symbol

PHF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5252

PubChem

5252

Alliance of Genome Resources

HGNC:8919

Annotation

Keyword

3D-structure
Alternative splicing
Chromatin regulator
Chromosomal rearrangement
Cytoskeleton
DNA damage
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Repressor
Transcription regulation
Zinc-finger

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A1U9X8A3	Polycomb-like protein 1
O43189	Polycomb-like protein 1
A0A140VJR4	Polycomb-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
negative regulation of gene expression, epigenetic	IBA
DNA repair-dependent chromatin remodeling	IDA	23142980

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

DNA repair-dependent chromatin remodeling

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
nucleus	IDA	23273982
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
centrosome	IDA	20873783

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

PcG protein complex [inference]

ESC/E(Z) complex

histone methyltransferase complex [inference]

ESC/E(Z) complex

catalytic complex [inference]

transferase complex [inference]

methyltransferase complex [inference]

histone methyltransferase complex [inference]

ESC/E(Z) complex

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

centrosome

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

site of DNA damage [inference]

site of double-strand break

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
transcription corepressor binding	IPI	29628311
DNA binding	IBA
chromatin binding	IBA
protein binding	IPI	11571280 16189514 21516116 23142980 24981860 25416956 26496610 27705803 29628311 31515488 32296183 33961781 34591612
zinc ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

transcription factor binding [inference]

transcription coregulator binding [inference]

transcription corepressor binding

enzyme binding [inference]

histone methyltransferase binding

histone binding [inference]

methylated histone binding

identical protein binding

modification-dependent protein binding [inference]

methylation-dependent protein binding [inference]

methylated histone binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

PHD finger protein 1

Functional Category

C: Energy production and conversion
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
chromatin binding
metal ion binding
methylated histone binding

Displaying **all 10** entries
InterPro
Lysine-specific demethylase 4-like, Tudor domain
PHD finger protein 1, PHD finger 2
PHD finger protein 1, Tudor domain
Polycomb-like MTF2 factor 2, C-terminal domain
Tudor domain
Zinc finger, FYVE/PHD-type
Zinc finger, PHD-finger
Zinc finger, PHD-type, conserved site
Zinc finger, PHD-type
Zinc finger, RING/FYVE/PHD-type

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Last updated: December 8, 2025