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phosphorylase kinase catalytic subunit gamma 2

Summary

Gene Symbol

PHKG2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5261

PubChem

5261

Alliance of Genome Resources

HGNC:8931

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Calmodulin-binding
Disease variant
Glycogen metabolism
Glycogen storage disease
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
P15735	PSK-C3 Phosphorylase kinase subunit gamma-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
generation of precursor metabolites and energy	TAS	8896567
protein phosphorylation	IEA
glycogen catabolic process	IEA
positive regulation of glycogen catabolic process	TAS	10487978
glycogen metabolic process	IBA TAS	8896567

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

glucan catabolic process [inference]

glycogen catabolic process

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

carbohydrate catabolic process [inference]

polysaccharide catabolic process [inference]

glucan catabolic process [inference]

glycogen catabolic process

cellular process [inference]

signal transduction

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

glycogen catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of carbohydrate catabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of carbohydrate catabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular process [inference]

signal transduction

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phosphorylase kinase complex	IBA TAS	10487978
cytosol	IDA TAS
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

serine/threonine protein kinase complex [inference]

phosphorylase kinase complex

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
phosphorylase kinase activity	IBA TAS	10487978
protein binding	IPI	23455922 26496610 28514442 32296183 32707033 33961781 35271311
calmodulin binding	IEA
enzyme binding	IEA
protein serine/threonine kinase activity	TAS	10487978

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

calmodulin-dependent protein kinase activity [inference]

phosphorylase kinase activity

tau-protein kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

calmodulin-dependent protein kinase activity [inference]

phosphorylase kinase activity

tau-protein kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

calmodulin-dependent protein kinase activity [inference]

phosphorylase kinase activity

tau-protein kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
calmodulin binding
glycogen biosynthetic process
glycogen metabolic process
nucleotide binding

Displaying **all 5** entries
InterPro
Phosphorylase kinase, gamma catalytic subunit
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111043	glycogen storage disease IXc	Alliance of Genome Resources
DOID:2747	glycogen storage disease	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	32120		FB:FBgn0011754
Mus musculus	68961		MGI:1916211	MOUSE53184
Rattus norvegicus	140671		RGD:620024	RATNO18541
Caenorhabditis elegans	190101		WB:WBGene00021753
Danio rerio	393937		ZFIN:ZDB-GENE-040426-825	DANRE04004
Xenopus laevis	496328		Xenbase:XB-GENE-994733
Bos taurus	512670			BOVIN20615
Canis lupus familiaris	607275			CANLF16385
Pan troglodytes	741602	9598_0:0040e2
Xenopus tropicalis	779740		Xenbase:XB-GENE-994728

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements