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squalene epoxidase

Summary

Gene Symbol

SQLE

Organism

Bos taurus (cattle)

External Links

NCBI Gene: 526535
KEGG Gene ID: bta:526535
PubChem: 526535

Annotation

Keyword

Endoplasmic reticulum
FAD
Monooxygenase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
A5D9A8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
sterol biosynthetic process	IEA	30032202
cholesterol metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

sterol metabolic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA	30032202
membrane	IEA	22301074

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
flavin adenine dinucleotide binding	IEA	22301074
squalene monooxygenase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

squalene monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

squalene monooxygenase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00511

Name

squalene monooxygenase [EC:1.14.14.17]

References

17852349

Rhea

O₂ + squalene

H₂O + H⁺ + (S)-2,3-epoxysqualene

Enzyme

1.14.14.17

PMID

Ortholog

Displaying entries **41 - 50** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	20775		MOUSE15196
Rattus norvegicus	29230		RATNO39255
Cavia porcellus	100732653		CAVPO17266
Octodon degus	101566440		OCTDE12122
Melopsittacus undulatus	101874506		MELUD14584
Monodelphis domestica	100032247		MONDO18704
Pelodiscus sinensis	102444614		PELSI18074
Anolis carolinensis	100557553		ANOCA05296
Ursus maritimus	103661624		URSMA06719
Bos indicus x Bos taurus	113904114		BOBOX30426

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

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Last updated: August 19, 2024