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ATPase H+ transporting V1 subunit E1

Summary

Gene Symbol

ATP6V1E1

Organism

Homo sapiens (human)

External Links

NCBI Gene

529

PubChem

529

Alliance of Genome Resources

HGNC:857

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Cytoplasmic vesicle
Direct protein sequencing
Disease variant
Hydrogen ion transport
Ion transport
Phosphoprotein
Reference proteome
Synapse

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q53Y06	V-type proton ATPase subunit e 1 Vacuolar proton pump subunit E 1
P36543	V-ATPase 31 kDa subunit Vacuolar proton pump subunit E 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
synaptic vesicle lumen acidification	IEA
regulation of macroautophagy	NAS	22982048
proton transmembrane transport	TAS	8250920

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

homeostatic process [inference]

cellular homeostasis [inference]

neuron cellular homeostasis [inference]

synaptic vesicle lumen acidification

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

synaptic vesicle lumen acidification

establishment of localization in cell [inference]

synaptic vesicle lumen acidification

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
synaptic vesicle membrane	IEA
microvillus	IEA
apical plasma membrane	ISS
vacuolar proton-transporting V-type ATPase, V1 domain	IDA	33065002
endosome	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

proton-transporting two-sector ATPase complex

proton-transporting two-sector ATPase complex, catalytic domain [inference]

proton-transporting V-type ATPase, V1 domain [inference]

vacuolar proton-transporting V-type ATPase, V1 domain

catalytic complex [inference]

ATPase complex [inference]

proton-transporting two-sector ATPase complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

plasma membrane region [inference]

apical plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11399750 16169070 21784977 35271311
proton-transporting ATPase activity, rotational mechanism	IBA
ATPase binding	IPI	20717956

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled ion transmembrane transporter activity [inference]

ATPase activity, coupled to transmembrane movement of ions, rotational mechanism [inference]

proton-transporting ATPase activity, rotational mechanism

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

binding [inference]

protein binding

enzyme binding [inference]

ATPase binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled ion transmembrane transporter activity [inference]

ATPase activity, coupled to transmembrane movement of ions, rotational mechanism [inference]

proton-transporting ATPase activity, rotational mechanism

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATPase

Functional Category

C: Energy production and conversion
D: Cell cycle control, cell division, chromosome partitioning
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
monoatomic ion transport
proton-transporting ATPase activity, rotational mechanism

Displaying **all 2** entries
InterPro
V-type ATPase subunit E, C-terminal domain superfamily
V-type ATPase subunit E

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070140	autosomal recessive cutis laxa type IIC	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 91 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	11973		MGI:894326	MOUSE50819
Drosophila melanogaster	40679		FB:FBgn0283535
Caenorhabditis elegans	177442		WB:WBGene00006917
Danio rerio	192335		ZFIN:ZDB-GENE-020419-11	DANRE32648
Bos taurus	287017			BOVIN30606
Rattus norvegicus	297566		RGD:735157	RATNO30533
Xenopus laevis	379457		Xenbase:XB-GENE-6255807
Xenopus tropicalis	394728		Xenbase:XB-GENE-1006142
Pan troglodytes	458633	9598_0:0054a3
Canis lupus familiaris	477740			CANLF11229

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 9, 2024