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phospholipase C beta 4

Summary

Gene Symbol

PLCB4

Organism

Homo sapiens (human)

External Links

NCBI Gene

5332

HGNC

9059

KEGG Gene ID

hsa:5332

PubChem

5332

Alliance of Genome Resources

HGNC:9059

Annotation

Keyword

Acetylation
Alternative splicing
Calcium
Cell membrane
Coiled coil
Direct protein sequencing
Disease variant
Hydrolase
Lipid degradation
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Transducer

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A7P0MRI8
Q15147	Phosphoinositide phospholipase C-beta-4 Phospholipase C-beta-4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway
release of sequestered calcium ion into cytosol	IBA
phosphatidylinositol metabolic process	IBA
phosphatidylinositol-mediated signaling	IBA
lipid catabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol
plasma membrane	IDA	35284927

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phospholipase C activity
calcium ion binding	IEA
protein binding	IPI	25416956 32296183
phosphatidylinositol phospholipase C activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity

phosphatidylinositol phospholipase C activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000101333

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K05858

Name

phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]

References

Rhea

RHEA:33179

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

H⁺ + a 1,2-diacyl-sn-glycerol + 1D-myo-inositol 1,4,5-trisphosphate

Enzyme

3.1.4.11

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **120** in total

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DO ID	Disease Name	Source
DOID:0050540	Charcot-Marie-Tooth disease type 3	DisGeNET
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:0050848	obstructive sleep apnea	DisGeNET
DOID:0050908	myelodysplastic syndrome	DisGeNET
DOID:0060260	ptosis	DisGeNET
DOID:6873	skin tag	DisGeNET
DOID:0060261	congenital ptosis	DisGeNET
DOID:0060600	obsolete hereditary motor and sensory neuropathy with agenesis of the corpus callosum	DisGeNET
DOID:0060843	hereditary neuropathy with liability to pressure palsies	DisGeNET
DOID:0070309	absence epilepsy	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000160	Narrow mouth
HP:0000162	Glossoptosis
HP:0000171	Microglossia
HP:0000175	Cleft palate
HP:0000183	Difficulty in tongue movements
HP:0000193	Bifid uvula
HP:0000256	Macrocephaly
HP:0000293	Full cheeks

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:614669	auriculocondylar syndrome 2
ORPHA:137888	auriculocondylar syndrome

PubChem Disease

GHR Health Conditions

Auriculo-condylar syndrome

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Auriculocondylar syndrome

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000593
Gene Name: phospholipase C, beta 4

Ortholog

Displaying entries **1 - 10** of 89 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178537	WB:WBGene00001177
Drosophila melanogaster	31376	FB:FBgn0262738
Latimeria chalumnae	102348275		LATCH05699
Lepisosteus oculatus	102682149		LEPOC00681
Danio rerio	407700	ZFIN:ZDB-GENE-060627-1
Astyanax mexicanus	103022380		ASTMX16480
Electrophorus electricus	113589466		ELEEL05915
Esox lucius	105017521		ESOLU53309
Salmo trutta	115172765		SALTR24986
Salmo trutta	115174483		SALTR53218

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements