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phospholipase C delta 1

Summary

Gene Symbol

PLCD1

Aliases

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
Phospholipase C δ1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5333

HGNC

9060

KEGG Gene ID

hsa:5333

PubChem

5333

Alliance of Genome Resources

HGNC:9060

Annotation

Keyword

Alternative splicing
Calcium
Disease variant
Glycoprotein
Hydrolase
Lipid degradation
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Transducer

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A8K8F9
A0A384MR47
P51178	Phosphoinositide phospholipase C-delta-1 Phospholipase C-III Phospholipase C-delta-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
release of sequestered calcium ion into cytosol	IBA
phosphatidylinositol metabolic process	IBA IDA	9188725
phospholipid metabolic process	TAS	9588182
lipid catabolic process	IEA
phosphatidylinositol-mediated signaling	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA IDA	15702972
plasma membrane	TAS
extracellular exosome	HDA	19056867

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
GTPase activating protein binding	IPI	18434237
calcium ion binding	IEA
phosphatidic acid binding	IEA
protein binding	IPI	32296183
phosphatidylserine binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

binding [inference]

protein binding

GTPase activating protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylserine binding

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

phosphatidic acid binding

ion binding [inference]

anion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
lipid metabolic process
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

Displaying **all 7** entries
InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phospholipase C, phosphatidylinositol-specific, Y domain

Human Protein Atlas

ENSG00000187091

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K05857

Name

phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]

References

Rhea

RHEA:33179

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

H⁺ + a 1,2-diacyl-sn-glycerol + 1D-myo-inositol 1,4,5-trisphosphate

Enzyme

3.1.4.11

PMID

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080081	nonsyndromic congenital nail disorder 3	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 15 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000498	Blepharitis
HP:0000499	Abnormal eyelash morphology
HP:0000613	Photophobia
HP:0000787	Nephrolithiasis
HP:0001231	Abnormal fingernail morphology
HP:0001595	Abnormal hair morphology
HP:0001598	Concave nail
HP:0001820	Leukonychia

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:2387	leukonychia totalis nonsyndromic congenital nail disorder 3
OMIM:151600	nonsyndromic congenital nail disorder 3

PubChem Disease

MedGen Diseases

Nonsyndromic congenital nail disorder 3

OMIM Phenotypes

NAIL DISORDER, NONSYNDROMIC CONGENITAL, 3; NDNC3

KEGG Diseases

Nonsyndromic congenital nail disorder

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002087
Gene Name: phospholipase C, delta 1

Ortholog

Displaying entries **1 - 10** of **100** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	18799		MGI:97614	MOUSE63963
Rattus norvegicus	24655		RGD:3346	RATNO41651
Caenorhabditis elegans	177525		WB:WBGene00004039
Bos taurus	281986			BOVIN17250
Danio rerio	337489		ZFIN:ZDB-GENE-030131-9435	DANRE30210
Pan troglodytes	460267	9598_0:000efa		PANTR30767
Danio rerio	555443		ZFIN:ZDB-GENE-071004-78
Macaca mulatta	696860			MACMU28537
Saccharomyces cerevisiae S288C	855860		SGD:S000006189
Ornithorhynchus anatinus	100083809			ORNAN05269

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements