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phospholipase C like 1 (inactive)

Summary

Gene Symbol

PLCL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5334

PubChem

5334

Alliance of Genome Resources

HGNC:9063

Annotation

Keyword

Alternative splicing
Coiled coil
Cytoplasm
Phosphoprotein
Reference proteome
Transducer

Proteins

Displaying 1 entry
UniProt	Protein Name
Q15111	Phospholipase C-deleted in lung carcinoma Phospholipase C-related but catalytically inactive protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
negative regulation of cold-induced thermogenesis	ISS	26706316
regulation of synaptic transmission, GABAergic	IBA
intracellular signal transduction	IEA
gamma-aminobutyric acid signaling pathway	IBA
lipid metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

signal transduction [inference]

intracellular signal transduction

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

negative regulation of cold-induced thermogenesis

Displaying 1 entry
GO Term	Evidence Code	PMID
cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phospholipase C activity	TAS	7633416
phosphatidylinositol phospholipase C activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity

phosphatidylinositol phospholipase C activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
lipid metabolic process
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

Displaying **all 7** entries
InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phospholipase C, phosphatidylinositol-specific, Y domain

Ortholog

Displaying entries **41 - 50** of 75 in total

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Species	Gene ID	Orthologous MAtrix
Pelodiscus sinensis	102450396	PELSI16298
Vicugna pacos	102541430	VICPA06634
Erinaceus europaeus	103123750	ERIEU12356
Callorhinchus milii	103182893	CALMI26043
Chlorocebus sabaeus	103217592	CHLSB01498
Carlito syrichta	103273046	CARSF16853
Ursus maritimus	103659717	URSMA01396
Nannospalax galili	103734474	NANGA11746
Serinus canaria	103814519	SERCA07081
Rhinopithecus roxellana	104676755	RHIRO12998