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phospholipase D2

Summary

Gene Symbol

PLD2

Aliases

choline phosphatase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5338

HGNC

9068

KEGG Gene ID

hsa:5338

PubChem

5338

Alliance of Genome Resources

HGNC:9068

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Hydrolase
Lipid degradation
Lipoprotein
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
O14939	Choline phosphatase 2 PLD1C Phosphatidylcholine-hydrolyzing phospholipase D2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
cytoskeleton organization		9395408
synaptic vesicle recycling		24252804
regulation of vesicle-mediated transport	IBA
Fc-gamma receptor signaling pathway involved in phagocytosis
phospholipid catabolic process	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

immune response-regulating cell surface receptor signaling pathway involved in phagocytosis [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

immune response-regulating cell surface receptor signaling pathway involved in phagocytosis [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

immune response-regulating cell surface receptor signaling pathway involved in phagocytosis [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

intracellular signal transduction [inference]

small GTPase mediated signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

localization [inference]

establishment of localization [inference]

transport [inference]

synaptic vesicle recycling

establishment of localization in cell [inference]

synaptic vesicle recycling

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

immune response-regulating cell surface receptor signaling pathway involved in phagocytosis [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

immune response-regulating cell surface receptor signaling pathway involved in phagocytosis [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

immune response-regulating cell surface receptor signaling pathway involved in phagocytosis [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

Fc receptor mediated stimulatory signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

immune response-regulating cell surface receptor signaling pathway involved in phagocytosis [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

Fc receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway [inference]

Fc-gamma receptor signaling pathway involved in phagocytosis

intracellular signal transduction [inference]

small GTPase mediated signal transduction

regulation of vesicle-mediated transport

Displaying **all 5** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IBA
presynapse	IEA
endoplasmic reticulum membrane
plasma membrane
plasma membrane region	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

presynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phospholipase D activity	IBA TAS
N-acylphosphatidylethanolamine-specific phospholipase D activity	IEA
phosphatidylinositol binding	IEA
protein binding	IPI	16407827 17276458 17853892 22106281 32814053