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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
plectin
Summary
- Gene Symbol
-
- PLEC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Actin-binding
- Alternative splicing
- Cell junction
- Coiled coil
- Cytoskeleton
- Direct protein sequencing
- Disease variant
- Epidermolysis bullosa
- Limb-girdle muscular dystrophy
- Methylation
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repeat
- SH3 domain
- Proteins
| UniProt | Protein Name |
|---|---|
| Q15149 |
|
| A0A8I5KUE3 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| skeletal muscle fiber development | ||
| cellular response to fluid shear stress | ||
| cardiac muscle cell development | ||
| hemidesmosome assembly | ||
| intermediate filament cytoskeleton organization |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| intermediate filament cytoskeleton | ||
| focal adhesion | ||
| sarcolemma | ||
| plasma membrane | ||
| hemidesmosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| structural constituent of cytoskeleton | ||
| RNA binding | ||
| cadherin binding | ||
| structural constituent of muscle |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Plectin
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| intermediate filament bundle assembly |
| intermediate filament cytoskeleton organization |
| keratin filament binding |
| structural molecule activity |
| wound healing |
| InterPro |
|---|
| Plakin repeat superfamily |
| Plakin |
| Plectin repeat |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060736 | epidermolysis bullosa simplex Ogna type | |
| DOID:0090017 | epidermolysis bullosa simplex with muscular dystrophy | |
| DOID:0110285 | autosomal recessive limb-girdle muscular dystrophy type 2Q | |
| DOID:4644 | epidermolysis bullosa simplex |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 100147640 | HORSE43063 | |||
| 100194709 | SALSA96143 | |||
| 100321011 | ZFIN:ZDB-GENE-100917-2 | DANRE09928 | ||
| 100405931 | CALJA13516 | |||
| 100457094 | 9601_0:002415 | PONAB34990 | ||
| 100693701 | ORENI40787 | |||
| 100735713 | CAVPO21664 | |||
| 100941839 | OTOGA01385 | |||
| 100968141 | 9597_0:002675 | PANPA39051 | ||
| 101018472 | PAPAN39070 |
