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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
plectin
Summary
- Gene Symbol
-
- PLEC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Actin-binding
- Alternative splicing
- Cell junction
- Coiled coil
- Cytoskeleton
- Direct protein sequencing
- Disease variant
- Epidermolysis bullosa
- Limb-girdle muscular dystrophy
- Methylation
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repeat
- SH3 domain
- Proteins
| UniProt | Protein Name |
|---|---|
| Q15149 |
|
| A0A8I5KUE3 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| transmission of nerve impulse | ||
| establishment of skin barrier | ||
| cellular response to mechanical stimulus | ||
| cell morphogenesis | ||
| wound healing |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| mitochondrial outer membrane | ||
| costamere | ||
| brush border | ||
| dendrite | ||
| sarcoplasm |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| ankyrin binding | ||
| actin filament binding | ||
| dystroglycan binding | ||
| identical protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Plectin
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| intermediate filament bundle assembly |
| intermediate filament cytoskeleton organization |
| keratin filament binding |
| structural molecule activity |
| wound healing |
| InterPro |
|---|
| Plakin repeat superfamily |
| Plakin |
| Plectin repeat |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060736 | epidermolysis bullosa simplex Ogna type | |
| DOID:0090017 | epidermolysis bullosa simplex with muscular dystrophy | |
| DOID:0110285 | autosomal recessive limb-girdle muscular dystrophy type 2Q | |
| DOID:4644 | epidermolysis bullosa simplex |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 18810 | MGI:1277961 | MOUSE17356 | ||
| 64204 | RGD:621649 | RATNO37219 | ||
| 464454 | 9598_0:002692 | PANTR43437 | ||
| 482083 | CANLF03287 | |||
| 567639 | ZFIN:ZDB-GENE-030131-8984 | DANRE15437 | ||
| 699517 | MACMU44208 | |||
| 786966 | BOVIN05570 | |||
| 100014955 | MONDO18974 | |||
| 100076841 | ORNAN19763 | |||
| 100145182 | Xenbase:XB-GENE-6459396 |
