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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
plectin
Summary
- Gene Symbol
-
- PLEC
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Actin-binding
- Alternative splicing
- Cell junction
- Coiled coil
- Cytoskeleton
- Direct protein sequencing
- Disease variant
- Epidermolysis bullosa
- Limb-girdle muscular dystrophy
- Methylation
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repeat
- SH3 domain
- Proteins
| UniProt | Protein Name |
|---|---|
| Q15149 |
|
| A0A8I5KUE3 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| transmission of nerve impulse | ||
| establishment of skin barrier | ||
| cellular response to mechanical stimulus | ||
| cell morphogenesis | ||
| wound healing |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| intermediate filament cytoskeleton | ||
| focal adhesion | ||
| sarcolemma | ||
| plasma membrane | ||
| hemidesmosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| ankyrin binding | ||
| actin filament binding | ||
| dystroglycan binding | ||
| identical protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Plectin
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| intermediate filament bundle assembly |
| intermediate filament cytoskeleton organization |
| keratin filament binding |
| structural molecule activity |
| wound healing |
| InterPro |
|---|
| Plakin repeat superfamily |
| Plakin |
| Plectin repeat |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060736 | epidermolysis bullosa simplex Ogna type | |
| DOID:0090017 | epidermolysis bullosa simplex with muscular dystrophy | |
| DOID:0110285 | autosomal recessive limb-girdle muscular dystrophy type 2Q | |
| DOID:4644 | epidermolysis bullosa simplex |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 105536355 | MANLE24519 | |||
| 105581224 | CERAT34259 | |||
| 105731525 | AOTNA38150 | |||
| 105813384 | PROCO03041 | |||
| 106583613 | SALSA106376 | |||
| 106841860 | EQUAS29961 | |||
| 107563701 | SINGR73928 | |||
| 107592072 | SINGR08038 | |||
| 108270367 | ICTPU14373 | |||
| 108536581 | RHIBE22522 |
