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Sulfated

Summary

Gene Symbol

Sulf1

Organism

Drosophila melanogaster (fruit fly)

External Links

NCBI Gene

53437

PubChem

53437

Alliance of Genome Resources

FB:FBgn0040271

Annotation

Keyword

Calcium
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Hydrolase
Metal-binding
Proteomics identification
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9VEX0
D1Z367

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
heparin metabolic process	IGI	20637191
wing disc anterior/posterior pattern formation	IMP	21806980
wing disc dorsal/ventral pattern formation	IMP	21305649
negative regulation of canonical Wnt signaling pathway	IMP	20637191 21305649
negative regulation of epidermal growth factor receptor signaling pathway	IGI	22595244

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

glycosaminoglycan metabolic process [inference]

mucopolysaccharide metabolic process [inference]

heparin metabolic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

heparin metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

glycosaminoglycan metabolic process [inference]

mucopolysaccharide metabolic process [inference]

heparin metabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

glycosaminoglycan metabolic process [inference]

mucopolysaccharide metabolic process [inference]

heparin metabolic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

glycosaminoglycan metabolic process [inference]

mucopolysaccharide metabolic process [inference]

heparin metabolic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

heparin metabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

motor neuron axon guidance

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

imaginal disc pattern formation [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

wing disc pattern formation [inference]

anterior/posterior pattern specification [inference]

anterior/posterior pattern specification, imaginal disc [inference]

wing disc anterior/posterior pattern formation

dorsal/ventral pattern formation [inference]

dorsal/ventral pattern formation, imaginal disc [inference]

wing disc dorsal/ventral pattern formation

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

synaptic target inhibition

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of smoothened signaling pathway [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of ERBB signaling pathway [inference]

regulation of epidermal growth factor receptor signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of smoothened signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of ERBB signaling pathway [inference]

negative regulation of epidermal growth factor receptor signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cell surface
Golgi stack
endoplasmic reticulum
extracellular space	IDA	21305649

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
N-acetylglucosamine-6-sulfatase activity	IMP	20637191
metal ion binding
glycosaminoglycan binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

sulfuric ester hydrolase activity [inference]

N-acetylglucosamine-6-sulfatase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sulfatase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
N-acetylglucosamine-6-sulfatase activity
glycosaminoglycan binding
hydrolase activity
sulfuric ester hydrolase activity

Displaying **all 3** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
Sulfatase, N-terminal
Sulfatase, conserved site

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:21305649

Ortholog

Displaying entries **1 - 10** of 49 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	23213	HGNC:20391
Homo sapiens	55959	HGNC:20392
Mus musculus	72043	MGI:1919293
Rattus norvegicus	171396	RGD:708554
Caenorhabditis elegans	180619	WB:WBGene00006308
Mus musculus	240725	MGI:2138563
Rattus norvegicus	311642	RGD:1305078
Danio rerio	322056	ZFIN:ZDB-GENE-030131-775
Danio rerio	337298	ZFIN:ZDB-GENE-030131-9242
Danio rerio	393910	ZFIN:ZDB-GENE-040426-759