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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
proteolipid protein 1
Summary
- Gene Symbol
-
- PLP1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Hereditary spastic paraplegia
- Leukodystrophy
- Palmitate
- Phosphoprotein
- Reference proteome
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| A8K9L3 |
|
| A0A0S2Z4D4 |
|
| P60201 |
|
| B4DI30 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| axon development | ||
| axon ensheathment | ||
| substantia nigra development | ||
| central nervous system myelination | ||
| positive regulation of gene expression |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| integrin alphav-beta3 complex | ||
| plasma membrane | ||
| myelin sheath | ||
| synapse |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| protein-containing complex binding | ||
| identical protein binding | ||
| structural constituent of myelin sheath | ||
| structural molecule activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Neuronal Membrane GlycoProtein
- Functional Category
-
- E: Amino acid transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| neuron projection development |
| InterPro |
|---|
| Myelin proteolipid protein PLP, conserved site |
| Myelin proteolipid protein PLP |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110773 | hereditary spastic paraplegia 2 | |
| DOID:1059 | intellectual disability | |
| DOID:11832 | visual epilepsy | |
| DOID:1596 | depressive disorder | |
| DOID:3210 | Pelizaeus-Merzbacher disease | |
| DOID:3213 | demyelinating disease |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 18823 | MGI:97623 | MOUSE65607 | ||
| 24943 | RGD:3354 | RATNO44544 | ||
| 40383 | FB:FBgn0037092 | |||
| 64264 | ZFIN:ZDB-GENE-001202-1 | DANRE07242 | ||
| 184437 | WB:WBGene00017437 | |||
| 281410 | BOVIN36660 | |||
| 368234 | ZFIN:ZDB-GENE-030710-6 | DANRE36055 | ||
| 379423 | Xenbase:XB-GENE-6255820 | |||
| 398334 | Xenbase:XB-GENE-1008585 | |||
| 465785 | 9598_0:00575a | PANTR46503 |
