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plastin 1

Summary

Gene Symbol

PLS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5357

PubChem

5357

Alliance of Genome Resources

HGNC:9090

JoGo

PLS1

TogoVar

PLS1

Annotation

Keyword

Acetylation
Actin-binding
Calcium
Cell projection
Cytoplasm
Disease variant
Metal-binding
Non-syndromic deafness
Phosphoprotein
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q14651	Intestine-specific plastin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
intestinal D-glucose absorption	IEA
regulation of microvillus length	IEA
positive regulation of multicellular organism growth	IEA
actin filament bundle assembly	IBA
actin filament network formation	IBA

GO Hierarchy

biological process

cellular process [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

terminal web assembly

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

terminal web assembly

cortical cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

terminal web assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

terminal web assembly

cellular component assembly [inference]

actin filament bundle assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

terminal web assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

inner ear receptor cell stereocilium organization [inference]

neuron projection organization [inference]

vestibular receptor cell stereocilium organization

regulation of cellular component size [inference]

regulation of cell projection size [inference]

regulation of microvillus length

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament network formation

actin filament bundle organization [inference]

actin filament bundle assembly

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal hexose absorption [inference]

intestinal D-glucose absorption

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption [inference]

intestinal hexose absorption [inference]

intestinal D-glucose absorption

organic substance transport [inference]

carbohydrate transport [inference]

intestinal hexose absorption [inference]

intestinal D-glucose absorption

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of growth [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

positive regulation of multicellular organism growth

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

positive regulation of multicellular organismal process [inference]

positive regulation of multicellular organism growth

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

positive regulation of multicellular organism growth

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of microvillus organization [inference]

regulation of microvillus length

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

positive regulation of protein localization to plasma membrane

positive regulation of protein localization to membrane [inference]

positive regulation of protein localization to plasma membrane

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth [inference]

positive regulation of multicellular organism growth

positive regulation of multicellular organismal process [inference]

positive regulation of multicellular organism growth

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell projection size [inference]

regulation of microvillus length

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytosol	IDA
actin filament	IBA
plasma membrane	IDA
brush border	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

actin filament bundle

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

stereocilium

actin-based cell projection [inference]

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton [inference]

terminal web

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton [inference]

terminal web

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cluster of actin-based cell projections [inference]

brush border

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying **all 3** entries
GO Term	Evidence Code	PMID
structural constituent of cytoskeleton	TAS	8139549
calcium ion binding	IEA
actin filament binding	IBA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fimbrin

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
actin binding
actin filament binding
actin filament network formation
calcium ion binding

Displaying **all 6** entries
InterPro
Actinin-type actin-binding domain, conserved site
CH domain superfamily
Calponin homology domain
EF-hand domain pair
EF-hand domain
Fimbrin/Plastin

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112167	autosomal dominant nonsyndromic deafness 76	Alliance of Genome Resources

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements