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ADAM metallopeptidase domain 22
Summary
- Gene Symbol
-
- ADAM22
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell adhesion
- Cell membrane
- Cell projection
- Cleavage on pair of basic residues
- Disease variant
- Disulfide bond
- EGF-like domain
- Epilepsy
- Glycoprotein
- Phosphoprotein
- Proteomics identification
- Receptor
- Reference proteome
- Signal
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| cell adhesion | ||
| negative regulation of cell adhesion | ||
| central nervous system development |
GO Hierarchy
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| metalloendopeptidase activity | ||
| integrin binding | ||
| protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Disintegrin
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| metal ion binding |
| metalloendopeptidase activity |
| metallopeptidase activity |
| proteolysis |
| InterPro |
|---|
| ADAM, cysteine-rich domain |
| Disintegrin domain superfamily |
| Disintegrin domain |
| Metallopeptidase, catalytic domain superfamily |
| Peptidase M12B, ADAM/reprolysin |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080434 | developmental and epileptic encephalopathy 61 |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 4185 | FB:FBgn0259110 | ||
| 8745 | FB:FBgn0259110 | ||
| 11488 | FB:FBgn0259110 | ||
| 11495 | WB:WBGene00006804 | ||
| 11496 | Xenbase:XB-GENE-957019 | MOUSE43947 | |
| 23792 | FB:FBgn0259110 | ||
| 23793 | WB:WBGene00006804 | ||
| 53616 | Xenbase:XB-GENE-957019 | ||
| 56777 | FB:FBgn0259110 | ||
| 56806 | FB:FBgn0259110 |
