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fucosyltransferase 8

Summary

Gene Symbol

Fut8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

53618

KEGG Gene ID

mmu:53618

PubChem

53618

Alliance of Genome Resources

MGI:1858901

Annotation

Keyword

3D-structure
Disulfide bond
Glycosyltransferase
Golgi apparatus
Phosphoprotein
Reference proteome
SH3 domain
SH3-binding
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9WTS2	Fucosyltransferase 8 GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase GDP-fucose--glycoprotein fucosyltransferase Glycoprotein 6-alpha-L-fucosyltransferase
B2X2D7
B2X2D8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
N-glycan fucosylation	IBA IMP	24619415
GDP-L-fucose metabolic process	ISO ISS
transforming growth factor beta receptor signaling pathway	IMP	16236725
receptor metabolic process	IMP	16236725
respiratory gaseous exchange by respiratory system	IMP	16236725

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

phosphorus metabolic process [inference]

GDP-L-fucose metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

glycosylation [inference]

fucosylation [inference]

N-glycan fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

receptor metabolic process

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

protein N-linked glycosylation via asparagine

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

phosphorus metabolic process [inference]

GDP-L-fucose metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

GDP-L-fucose metabolic process

cell motility [inference]

cell migration

ameboidal-type cell migration [inference]

fibroblast migration

multicellular organismal process [inference]

respiratory gaseous exchange by respiratory system

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

regulation of response to oxidative stress [inference]

regulation of cellular response to oxidative stress

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
alpha-(1->6)-fucosyltransferase activity	IBA IMP	16236725 17043354
SH3 domain binding	IEA
glycoprotein 6-alpha-L-fucosyltransferase activity	ISO ISS
glycosyltransferase activity	ISA	10902914

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

hexosyltransferase activity [inference]

fucosyltransferase activity [inference]

alpha-(1->6)-fucosyltransferase activity

glycoprotein 6-alpha-L-fucosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein 6-alpha-L-fucosyltransferase activity

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

SH3 domain binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

alpha-(1,6)-fucosyltransferase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
N-glycan fucosylation
SH3 domain binding
alpha-(1->6)-fucosyltransferase activity
glycoprotein 6-alpha-L-fucosyltransferase activity
hexosyltransferase activity
protein N-linked glycosylation
transferase activity

Displaying **all 6** entries
InterPro
Alpha-(1,6)-fucosyltransferase, N- and catalytic domain
Alpha-(1,6)-fucosyltransferase, SH3 domain
Alpha-(1,6)-fucosyltransferase
Glycosyltransferase family 23 (GT23) domain
SH3 domain
SH3-like domain superfamily

KEGG BRITE Database

Orthology

K00717

Name

glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68]

References

8910378

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R09319	2.4.1.68	G61751GZ	G07483YN
R05988	2.4.1.68	G39213VZ	G80858MF

Rhea

RHEA:12985

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.68

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9675	pulmonary emphysema	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **137** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2530		HGNC:4019	HUMAN19855
Drosophila melanogaster	32122		FB:FBgn0030327
Caenorhabditis elegans	178985		WB:WBGene00001508
Bos taurus	281177			BOVIN01570
Sus scrofa	396933			PIGXX32700
Xenopus tropicalis	407913		Xenbase:XB-GENE-954943
Rattus norvegicus	432392	10116_1:0024a5	RGD:1303096	RATNO36499
Takifugu rubripes	445893			TAKRU13930
Canis lupus familiaris	448804			CANLF18005
Pan troglodytes	449506			PANTR08984